Literature DB >> 16494492

Rubriflordilactones A and B, two novel bisnortriterpenoids from Schisandra rubriflora and their biological activities.

Wei-Lie Xiao1, Liu-Meng Yang, Ning-Bo Gong, Li Wu, Rui-Rui Wang, Jian-Xin Pu, Xiao-Li Li, Sheng-Xiong Huang, Yong-Tang Zheng, Rong-Tao Li, Yang Lu, Qi-Tai Zheng, Han-Dong Sun.   

Abstract

Rubriflordilactones A (1) and B (2), two novel highly unsaturated rearranged bisnortriterpenoids possessing a biosynthetically modified aromatic D-ring, were isolated from the leaves and stems of Schisandra rubriflora. Their structures were established on the basis of extensive spectroscopic methods, including two-dimensional NMR techniques, and confirmed by X-ray crystallographic analysis. Compound 1 showed weak anti-HIV-1 activity, and compound 2 exhibited an EC50 value of 9.75 microg/mL (SI=12.39) against HIV-1 replication with low cytotoxicity.

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Year:  2006        PMID： 16494492     DOI： 10.1021/ol060062f

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  11 in total

1.  Copper-catalyzed intramolecular alkene carboetherification: synthesis of fused-ring and bridged-ring tetrahydrofurans.

Authors:  Yan Miller; Lei Miao; Azade S Hosseini; Sherry R Chemler
Journal:  J Am Chem Soc       Date:  2012-07-05       Impact factor: 15.419

Review 2.  Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products.

Authors:  Zachary G Brill; Matthew L Condakes; Chi P Ting; Thomas J Maimone
Journal:  Chem Rev       Date:  2017-03-15       Impact factor: 60.622

3.  Schisantherin A exhibits anti-inflammatory properties by down-regulating NF-kappaB and MAPK signaling pathways in lipopolysaccharide-treated RAW 264.7 cells.

Authors:  Xinxin Ci; Rong Ren; Kan Xu; Hongyu Li; Qinlei Yu; Yu Song; Dacheng Wang; Rongtao Li; Xuming Deng
Journal:  Inflammation       Date:  2010-04       Impact factor: 4.092

Review 4.  Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents.

Authors:  Reen-Yen Kuo; Keduo Qian; Susan L Morris-Natschke; Kuo-Hsiung Lee
Journal:  Nat Prod Rep       Date:  2009-08-13       Impact factor: 13.423

5.  Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression.

Authors:  Yan-Ying Wang; Xin-Guang Qiu; Hong-Liang Ren
Journal:  Int J Clin Exp Pathol       Date:  2015-12-01

6.  Streamlined Catalytic Enantioselective Synthesis of α-Substituted β,γ-Unsaturated Ketones and Either of the Corresponding Tertiary Homoallylic Alcohol Diastereomers.

Authors:  Juan Del Pozo; Shaochen Zhang; Filippo Romiti; Shibo Xu; Ryan P Conger; Amir H Hoveyda
Journal:  J Am Chem Soc       Date:  2020-10-05       Impact factor: 15.419

7.  Isolation, Structural Elucidation of Three New Triterpenoids from the Stems and Leaves of Schisandra chinensis (Turcz) Baill.

Authors:  Feng Qiu; Han Liu; Huan Duan; Pian Chen; Shao-Juan Lu; Guang-Zhong Yang; Xin-Xiang Lei
Journal:  Molecules       Date:  2018-07-04       Impact factor: 4.411

Review 8.  Harvest, After 50 Years of Sowing.

Authors:  Pema-Tenzin Puno
Journal:  Nat Prod Bioprospect       Date:  2018-07-19

9.  Total Synthesis of (+)-Rubriflordilactone A.

Authors:  Shermin S Goh; Guilhem Chaubet; Birgit Gockel; Marie-Caroline A Cordonnier; Hannah Baars; Andrew W Phillips; Edward A Anderson
Journal:  Angew Chem Int Ed Engl       Date:  2015-09-04       Impact factor: 15.336

10.  Total Synthesis of the Schisandraceae Nortriterpenoid Rubriflordilactone A.

Authors:  Guilhem Chaubet; Shermin S Goh; Mujahid Mohammad; Birgit Gockel; Marie-Caroline A Cordonnier; Hannah Baars; Andrew W Phillips; Edward A Anderson
Journal:  Chemistry       Date:  2017-09-08       Impact factor: 5.236
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