Literature DB >> 16493831

The spore photoproduct lyase repairs the 5S- and not the 5R-configured spore photoproduct DNA lesion.

Marcus G Friedel1, Olivier Berteau, J Carsten Pieck, Mohamed Atta, Sandrine Ollagnier-de-Choudens, Marc Fontecave, Thomas Carell.   

Abstract

The spore photoproduct lyase is a Fe-S/AdoMet DNA repair enzyme, which directly repairs spore lesions, induced by UV irradiation of spores, using an unknown radical mechanism. The air sensitive radical SAM enzyme was for the first time challenged with synthetically pure substrates. It was found that the enzyme recognizes a synthetic 5S-configured spore lesion without the central phosphodiester bond. The 5R-configured lesion is in contrast to current belief not a substrate.

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Year:  2006        PMID： 16493831     DOI： 10.1039/b514103f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

1.  Anaerobic sulfatase-maturating enzyme--a mechanistic link with glycyl radical-activating enzymes?

Authors:  Alhosna Benjdia; Sowmya Subramanian; Jérôme Leprince; Hubert Vaudry; Michael K Johnson; Olivier Berteau
Journal:  FEBS J       Date:  2010-03-09       Impact factor: 5.542

Review 2.  Mechanistic studies of the radical SAM enzyme spore photoproduct lyase (SPL).

Authors:  Lei Li
Journal:  Biochim Biophys Acta       Date:  2011-12-08

3.  Spore photoproduct within DNA is a surprisingly poor substrate for its designated repair enzyme-The spore photoproduct lyase.

Authors:  Linlin Yang; Yajun Jian; Peter Setlow; Lei Li
Journal:  DNA Repair (Amst)       Date:  2017-03-06

4.  Complete stereospecific repair of a synthetic dinucleotide spore photoproduct by spore photoproduct lyase.

Authors:  Sunshine C Silver; Tilak Chandra; Egidijus Zilinskas; Shourjo Ghose; William E Broderick; Joan B Broderick
Journal:  J Biol Inorg Chem       Date:  2010-04-20       Impact factor: 3.358

Review 5.  Adenosyl radical: reagent and catalyst in enzyme reactions.

Authors:  E Neil G Marsh; Dustin P Patterson; Lei Li
Journal:  Chembiochem       Date:  2010-03-22       Impact factor: 3.164

6.  Chemical synthesis, crystal structure and enzymatic evaluation of a dinucleotide spore photoproduct analogue containing a formacetal linker.

Authors:  Gengjie Lin; Chun-Hsing Chen; Maren Pink; Jingzhi Pu; Lei Li
Journal:  Chemistry       Date:  2011-07-20       Impact factor: 5.236

7.  Spore photoproduct lyase catalyzes specific repair of the 5R but not the 5S spore photoproduct.

Authors:  Tilak Chandra; Sunshine C Silver; Egidijus Zilinskas; Eric M Shepard; William E Broderick; Joan B Broderick
Journal:  J Am Chem Soc       Date:  2009-02-25       Impact factor: 15.419

8.  Mechanistic studies of the spore photoproduct lyase via a single cysteine mutation.

Authors:  Linlin Yang; Gengjie Lin; Renae S Nelson; Yajun Jian; Joshua Telser; Lei Li
Journal:  Biochemistry       Date:  2012-08-31       Impact factor: 3.162

Review 9.  Photochemistry and Photobiology of the Spore Photoproduct: A 50-Year Journey.

Authors:  Peter Setlow; Lei Li
Journal:  Photochem Photobiol       Date:  2015-09-20       Impact factor: 3.421

10.  Combined Mössbauer spectroscopic, multi-edge X-ray absorption spectroscopic, and density functional theoretical study of the radical SAM enzyme spore photoproduct lyase.

Authors:  Sunshine C Silver; David J Gardenghi; Sunil G Naik; Eric M Shepard; Boi Hanh Huynh; Robert K Szilagyi; Joan B Broderick
Journal:  J Biol Inorg Chem       Date:  2014-02-16       Impact factor: 3.358
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