Literature DB >> 16493238

Tangle diseases and the tau haplotypes.

John Hardy1, Alan Pittman, Amanda Myers, Hon Chung Fung, Rohan de Silva, Jaime Duckworth.   

Abstract

Neurofibrillary tangles are found in many neurologic diseases. Here we review the unusual characteristics of the MAPT locus, which shows genetic association with many of these diseases and in Caucasian populations, is the largest stretch of linkage disequilibrium in the genome. We discuss the reason for this disequilibrium, its evolutionary history, and the role of genetic variability at MAPT in the etiology of tauopathies.

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Year:  2006        PMID： 16493238     DOI： 10.1097/01.wad.0000201853.54493.d8

Source DB:  PubMed          Journal:  Alzheimer Dis Assoc Disord        ISSN： 0893-0341            Impact factor:   2.703


  4 in total

1.  Runs of homozygosity reveal highly penetrant recessive loci in schizophrenia.

Authors:  Todd Lencz; Christophe Lambert; Pamela DeRosse; Katherine E Burdick; T Vance Morgan; John M Kane; Raju Kucherlapati; Anil K Malhotra
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-05       Impact factor: 11.205

2.  DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau.

Authors:  Jose F Abisambra; Umesh K Jinwal; Amirthaa Suntharalingam; Karthik Arulselvam; Sarah Brady; Matthew Cockman; Ying Jin; Bo Zhang; Chad A Dickey
Journal:  J Mol Biol       Date:  2012-02-15       Impact factor: 5.469

Review 3.  Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies.

Authors:  John Koren; Umesh K Jinwal; Zachary Davey; Janine Kiray; Karthik Arulselvam; Chad A Dickey
Journal:  Mol Neurobiol       Date:  2011-04-28       Impact factor: 5.590

4.  Tauopathy with paired helical filaments in an aged chimpanzee.

Authors:  Rebecca F Rosen; Aaron S Farberg; Marla Gearing; Jeromy Dooyema; Patrick M Long; Daniel C Anderson; Jeremy Davis-Turak; Giovanni Coppola; Daniel H Geschwind; Jean-Francois Paré; Timothy Q Duong; William D Hopkins; Todd M Preuss; Lary C Walker
Journal:  J Comp Neurol       Date:  2008-07-20       Impact factor: 3.215
  4 in total

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