| Literature DB >> 16492764 |
Taro Tamada1, Eijiro Honjo, Yoshitake Maeda, Tomoyuki Okamoto, Matsujiro Ishibashi, Masao Tokunaga, Ryota Kuroki.
Abstract
A crystal structure of the signaling complex between human granulocyte colony-stimulating factor (GCSF) and a ligand binding region of GCSF receptor (GCSF-R), has been determined to 2.8 A resolution. The GCSF:GCSF-R complex formed a 2:2 stoichiometry by means of a cross-over interaction between the Ig-like domains of GCSF-R and GCSF. The conformation of the complex is quite different from that between human GCSF and the cytokine receptor homologous domain of mouse GCSF-R, but similar to that of the IL-6/gp130 signaling complex. The Ig-like domain cross-over structure necessary for GCSF-R activation is consistent with previously reported thermodynamic and mutational analyses.Entities:
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Year: 2006 PMID： 16492764 PMCID： PMC1413920 DOI： 10.1073/pnas.0511264103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205