OBJECTIVE: To analyze the association between bacterial vaginosis (BV) in early pregnancy and preterm birth, low birth weight (LBW) and small for gestational age (SGA) in a Danish population. METHODS: A geographically defined population-based prospective study of Danish-speaking pregnant women over18 years of age enrolled before week 24 and followed until delivery. BV was diagnosed by Amsel's clinical criteria at enrolment. RESULTS: At enrolment, 13.7% had BV. BV was not associated with an increased risk of spontaneous preterm birth (crude OR 0.8 (0.5-1.5)). Nulliparity was found to affect birth weight to such a degree that this variable was used for stratification. In nulliparous women BV was associated with LBW (adj. OR 4.3 (1.5-12)) and SGA (adj. OR 1.6 (0.7-3.1)) compared to nulliparous without BV. No such associations were seen for multiparous women with BV. CONCLUSIONS: BV was not associated with spontaneous preterm birth, but was associated with both LBW and SGA in nulliparous women.
OBJECTIVE: To analyze the association between bacterial vaginosis (BV) in early pregnancy and preterm birth, low birth weight (LBW) and small for gestational age (SGA) in a Danish population. METHODS: A geographically defined population-based prospective study of Danish-speaking pregnant women over18 years of age enrolled before week 24 and followed until delivery. BV was diagnosed by Amsel's clinical criteria at enrolment. RESULTS: At enrolment, 13.7% had BV. BV was not associated with an increased risk of spontaneous preterm birth (crude OR 0.8 (0.5-1.5)). Nulliparity was found to affect birth weight to such a degree that this variable was used for stratification. In nulliparous women BV was associated with LBW (adj. OR 4.3 (1.5-12)) and SGA (adj. OR 1.6 (0.7-3.1)) compared to nulliparous without BV. No such associations were seen for multiparous women with BV. CONCLUSIONS: BV was not associated with spontaneous preterm birth, but was associated with both LBW and SGA in nulliparous women.
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