Literature DB >> 16492533

Induction of neutral endopeptidase activity in PC-3 cells by an aqueous extract of Epilobium angustifolium L. and oenothein B.

A Kiss1, J Kowalski, M F Melzig.   

Abstract

An aqueous extract of Epilobium angustifolium and its main compound oenothein B (OeB), a dimeric macrocyclic ellagitannin, are specifically able to induce the neutral endopeptidase (NEP) in prostate cancer cells. The angiotensin-converting enzyme (ACE) is not influenced. Additionally, a weak but statistically significant inhibition of cell proliferation is observed. Simultaneous treatment of the cells with arabinosylcytosine and the extract as well as the OeB, leads to an additional enhancement of NEP activity. Taking into account the role of this peptidase in prostate cancer progression, our results might offer a pharmacological explanation for the use of Epilobium in folk medicine.

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Year:  2005        PMID： 16492533     DOI： 10.1016/j.phymed.2004.08.002

Source DB:  PubMed          Journal:  Phytomedicine        ISSN： 0944-7113            Impact factor:   5.340


  11 in total

Review 1.  Structural features and biological properties of ellagitannins in some plant families of the order Myrtales.

Authors:  Takashi Yoshida; Yoshiaki Amakura; Morio Yoshimura
Journal:  Int J Mol Sci       Date:  2010-01-06       Impact factor: 6.208

2.  Immunomodulatory activity of oenothein B isolated from Epilobium angustifolium.

Authors:  Igor A Schepetkin; Liliya N Kirpotina; Larissa Jakiw; Andrei I Khlebnikov; Christie L Blaskovich; Mark A Jutila; Mark T Quinn
Journal:  J Immunol       Date:  2009-10-21       Impact factor: 5.422

Review 3.  Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).

Authors:  Igor A Schepetkin; Andrew G Ramstead; Liliya N Kirpotina; Jovanka M Voyich; Mark A Jutila; Mark T Quinn
Journal:  Phytother Res       Date:  2016-05-24       Impact factor: 5.878

4.  Oenothein B suppresses lipopolysaccharide (LPS)-induced inflammation in the mouse brain.

Authors:  Satoshi Okuyama; Nahomi Makihata; Morio Yoshimura; Yoshiaki Amakura; Takashi Yoshida; Mitsunari Nakajima; Yoshiko Furukawa
Journal:  Int J Mol Sci       Date:  2013-05-07       Impact factor: 5.923

Review 5.  Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer's disease.

Authors:  Natalia N Nalivaeva; Nikolai D Belyaev; Caroline Kerridge; Anthony J Turner
Journal:  Front Aging Neurosci       Date:  2014-09-17       Impact factor: 5.750

Review 6.  Chemical and Biological Significance of Oenothein B and Related Ellagitannin Oligomers with Macrocyclic Structure.

Authors:  Takashi Yoshida; Morio Yoshimura; Yoshiaki Amakura
Journal:  Molecules       Date:  2018-03-02       Impact factor: 4.411

Review 7.  Neprilysin expression and functions in development, ageing and disease.

Authors:  N N Nalivaeva; I A Zhuravin; A J Turner
Journal:  Mech Ageing Dev       Date:  2020-09-26       Impact factor: 5.432

8.  Oenothein B, a cyclic dimeric ellagitannin isolated from Epilobium angustifolium, enhances IFNγ production by lymphocytes.

Authors:  Andrew G Ramstead; Igor A Schepetkin; Mark T Quinn; Mark A Jutila
Journal:  PLoS One       Date:  2012-11-30       Impact factor: 3.240

9.  Cytotoxic effect of methanolic extract, alkaloid and terpenoid fractions of Stachys pilifera against HT-29 cell line.

Authors:  Esmaeel Panahi Kokhdan; Hossein Sadeghi; Hossin Ghafoori; Heibatollah Sadeghi; Nazanin Danaei; Hamedreza Javadian; Mahmoud Reza Aghamaali
Journal:  Res Pharm Sci       Date:  2018-10

10.  Essential Elements and Isoflavonoids in the Prevention of Prostate Cancer.

Authors:  Iwona J Stanisławska; Ramona Figat; Anna K Kiss; Barbara Bobrowska-Korczak
Journal:  Nutrients       Date:  2022-03-14       Impact factor: 5.717
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