OBJECTIVES: Stroke risk is increased in migraine, the basis of which remains to be established. C-reactive protein (CRP) is a marker of cerebrovascular disease, suggesting in part an inflammatory mechanism. Because attacks of migraine may involve repeated sterile vascular inflammation, we measured CRP in migraine patients. METHODS: Retrospective review was conducted of 60 randomly sampled charts of patients with the diagnosis of migraine without aura (MwoA, n = 29) and migraine with aura (MwA, n = 31), in which CRP was recorded as part of the differential diagnostic evaluation. CRP was measured by standard commercial laboratory methods; high sensitivity CRP (hs-CRP) values above 3mg/L were considered abnormal. RESULTS: Elevated hs-CRP was found in 43% of all patients (26 of 60). In MwoA, of 29 subjects, abnormal hs-CRP was recorded in 16; in 10 no other conditions were found to explain the abnormality. In MwA, of 31 subjects, abnormal CRP was recorded in 10; in 5 no other condition could explain the abnormality. No associations were found between other demographic or clinical features. CONCLUSIONS: CRP may be abnormal in MwoA and MwA patients who present with atypical, severe, or complex clinical features that require extensive differential diagnostic investigation.
OBJECTIVES:Stroke risk is increased in migraine, the basis of which remains to be established. C-reactive protein (CRP) is a marker of cerebrovascular disease, suggesting in part an inflammatory mechanism. Because attacks of migraine may involve repeated sterile vascular inflammation, we measured CRP in migrainepatients. METHODS: Retrospective review was conducted of 60 randomly sampled charts of patients with the diagnosis of migraine without aura (MwoA, n = 29) and migraine with aura (MwA, n = 31), in which CRP was recorded as part of the differential diagnostic evaluation. CRP was measured by standard commercial laboratory methods; high sensitivity CRP (hs-CRP) values above 3mg/L were considered abnormal. RESULTS: Elevated hs-CRP was found in 43% of all patients (26 of 60). In MwoA, of 29 subjects, abnormal hs-CRP was recorded in 16; in 10 no other conditions were found to explain the abnormality. In MwA, of 31 subjects, abnormal CRP was recorded in 10; in 5 no other condition could explain the abnormality. No associations were found between other demographic or clinical features. CONCLUSIONS:CRP may be abnormal in MwoA and MwA patients who present with atypical, severe, or complex clinical features that require extensive differential diagnostic investigation.
Authors: Yago Leira; Pablo Ameijeira; Clara Domínguez; Esteban López-Arias; Paulo Ávila-Gómez; María Pérez-Mato; Tomás Sobrino; Francisco Campos; Francesco D'Aiuto; Rogelio Leira; Juan Blanco Journal: Clin Oral Investig Date: 2019-05-20 Impact factor: 3.573
Authors: Sixto E Sanchez; Michelle A Williams; Percy N Pacora; Cande V Ananth; Chungfang Qiu; Sheena K Aurora; Tanya K Sorensen Journal: BMC Womens Health Date: 2010-10-26 Impact factor: 2.809
Authors: L S Gudmundsson; T Aspelund; A I Scher; G Thorgeirsson; M Johannsson; L J Launer; V Gudnason Journal: Cephalalgia Date: 2009-04-28 Impact factor: 6.292