Literature DB >> 16491845

Inhibitory activity of 6-O-angeloylprenolin from Centipeda minima on farnesyl protein transferase.

Hyun Mi Oh1, Byoung-Mog Kwon, Nam-In Baek, Sung-Hoon Kim, Jae Hyeok Lee, Jae Soon Eun, Jae Heon Yang, Dae Keun Kim.   

Abstract

The methanolic extract of the aerial parts of Centipeda minima was found to show inhibitory activity on farnesyl protein transferase (FPTase). Bioassay-guided fractionation of the methanolic extract resulted in the isolation of 6-O-angeloylprenolin, as an inhibitor on FPTase. This compound inhibited FPTase activity in a dose-dependent manner, and the IC50 value of 6-O-angeloylprenolin was 18.8 microM.

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Year:  2006        PMID： 16491845

Source DB:  PubMed          Journal:  Arch Pharm Res        ISSN： 0253-6269            Impact factor:   4.946


  3 in total

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Authors:  Karma Yeshi; Gerry Turpin; Tenzin Jamtsho; Phurpa Wangchuk
Journal:  Molecules       Date:  2022-06-15       Impact factor: 4.927

2.  Small compound 6-O-angeloylplenolin induces mitotic arrest and exhibits therapeutic potentials in multiple myeloma.

Authors:  Ying Liu; Xiao-Qin Chen; Heng-Xing Liang; Feng-Xiang Zhang; Bo Zhang; Jie Jin; Yong-Long Chen; Yong-Xian Cheng; Guang-Biao Zhou
Journal:  PLoS One       Date:  2011-07-06       Impact factor: 3.240

3.  6-O-angeloylplenolin exerts neuroprotection against lipopolysaccharide-induced neuroinflammation in vitro and in vivo.

Authors:  Yi-le Zhou; Yong-Ming Yan; Si-Yi Li; Dan-Hua He; Sha Xiong; Su-Fen Wei; Wei Liu; Ling Hu; Qi Wang; Hua-Feng Pan; Yong-Xian Cheng; Yong-Qiang Liu
Journal:  Acta Pharmacol Sin       Date:  2019-06-18       Impact factor: 6.150
  3 in total

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