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Literature DB >> 16490268

The ribosome as a drug target.

Abstract

The elucidation of the crystal structure of the ribosome and its subunits has dramatically increased our understanding of this organelle and the molecular interactions that determine its functional capabilities. Two recent publications, one on the structure of the bacterial ribosome at 3.5A resolution and one on the identification of functionally relevant sites within the small subunit rRNA, illustrate the importance of interdisciplinary approaches in exploiting the ribosome as a drug target.

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Year: 2006 PMID： 16490268 DOI： 10.1016/j.tibtech.2006.02.005

Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536

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Cited

11 in total

1. A modified fluorescent intercalator displacement assay for RNA ligand discovery.

Authors: Papa Nii Asare-Okai; Christine S Chow
Journal: Anal Biochem Date: 2010-09-21 Impact factor: 3.365

2. Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites.

Authors: Prabuddha Waduge; Girish C Sati; David Crich; Christine S Chow
Journal: Bioorg Med Chem Date: 2019-09-13 Impact factor: 3.641

3. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.

Authors: Tamar Auerbach; Inbal Mermershtain; Chen Davidovich; Anat Bashan; Matthew Belousoff; Itai Wekselman; Ella Zimmerman; Liqun Xiong; Dorota Klepacki; Kenji Arakawa; Haruyasu Kinashi; Alexander S Mankin; Ada Yonath
Journal: Proc Natl Acad Sci U S A Date: 2010-01-11 Impact factor: 11.205

Review 4. Large facilities and the evolving ribosome, the cellular machine for genetic-code translation.

Authors: Ada Yonath
Journal: J R Soc Interface Date: 2009-08-05 Impact factor: 4.118

5. Defining the RNA-protein interactions in the trypanosome preribosomal complex.

Authors: Lei Wang; Martin Ciganda; Noreen Williams
Journal: Eukaryot Cell Date: 2013-02-08

6. Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita.

Authors: Annageldi Tayyrov; Sophie Azevedo; Robert Herzog; Eva Vogt; Simon Arzt; Peter Lüthy; Pie Müller; Martin Rühl; Florian Hennicke; Markus Künzler
Journal: Appl Environ Microbiol Date: 2019-10-16 Impact factor: 4.792

The ribosome as a drug target.

1. A modified fluorescent intercalator displacement assay for RNA ligand discovery.

2. Use of a fluorescence assay to determine relative affinities of semisynthetic aminoglycosides to small RNAs representing bacterial and mitochondrial A sites.

3. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics.

Review 4. Large facilities and the evolving ribosome, the cellular machine for genetic-code translation.

5. Defining the RNA-protein interactions in the trypanosome preribosomal complex.

6. Heterologous Production and Functional Characterization of Ageritin, a Novel Type of Ribotoxin Highly Expressed during Fruiting of the Edible Mushroom Agrocybe aegerita.

7. The impact of aminoglycosides on the dynamics of translation elongation.

8. Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis.

9. Evidence for ligandable sites in structured RNA throughout the Protein Data Bank.

10. Analysis of small nucleolar RNAs reveals unique genetic features in malaria parasites.