| Literature DB >> 16490264 |
James D Jontes1, Greg R Phillips.
Abstract
How are appropriate connections between neurons sorted from the overwhelming surplus of potential, yet inappropriate, connections? Despite the apparently improbable nature of the process, brains wire themselves with a high degree of reproducibility that has been conserved across evolutionary history. Here, we outline a viable cell-biological model for generating synaptic specificity that features selection of nascent synapses based on adhesion and recognition. This process uses the highly dynamic and stochastic nature of intracellular trafficking to generate reproducible patterns of synaptic connectivity.Mesh：
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Year: 2006 PMID： 16490264 DOI： 10.1016/j.tins.2006.02.002
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837