Literature DB >> 16489442

alpha-fetoprotein expression in a dedifferentiated liposarcoma.

Martino Bosco1, Elena Allia, Jean-Michel Coindre, Chiara Odasso, Alberto Pagani, Donatella Pacchioni.   

Abstract

Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.

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Year:  2006        PMID： 16489442     DOI： 10.1007/s00428-006-0151-3

Source DB:  PubMed          Journal:  Virchows Arch        ISSN： 0945-6317            Impact factor:   4.064


  13 in total

1.  Paraneoplastic syndromes in cancer: Case 2. Leucocytosis associated with liposarcoma recurrence: original presentation of liposarcoma recurrence.

Authors:  Gaëtan des Guetz; Pascale Mariani; Paul Freneaux; Pierre Pouillart
Journal:  J Clin Oncol       Date:  2004-06-01       Impact factor: 44.544

2.  Stimulation of tumor-cell growth by alpha-fetoprotein.

Authors:  X W Wang; B Xu
Journal:  Int J Cancer       Date:  1998-02-09       Impact factor: 7.396

Review 3.  Alpha-fetoprotein in ontogenesis and its association with malignant tumors.

Authors:  G I Abelev
Journal:  Adv Cancer Res       Date:  1971       Impact factor: 6.242

4.  Prognostic factors in adult patients with locally controlled soft tissue sarcoma. A study of 546 patients from the French Federation of Cancer Centers Sarcoma Group.

Authors:  J M Coindre; P Terrier; N B Bui; F Bonichon; F Collin; V Le Doussal; A M Mandard; M O Vilain; J Jacquemier; H Duplay; X Sastre; C Barlier; M Henry-Amar; J Macé-Lesech; G Contesso
Journal:  J Clin Oncol       Date:  1996-03       Impact factor: 44.544

5.  Clinicopathologic features of gastric cancers producing alpha-fetoprotein.

Authors:  Koji Kono; Hideki Amemiya; Takayoshi Sekikawa; Hidehiko Iizuka; Akihiro Takahashi; Hideki Fujii; Yoshiro Matsumoto
Journal:  Dig Surg       Date:  2002       Impact factor: 2.588

6.  Further evidence of hepatic transdifferentiation in hepatoid adenocarcinomas of the stomach: quantitative analysis of mRNA for albumin and hepatocyte nuclear factor-4alpha.

Authors:  Tomoyuki Yano; Takashi Kishimoto; Utano Tomaru; You Kawarada; Hiroyuki Kato; Takashi Yoshiki; Hiroshi Ishikura
Journal:  Pathology       Date:  2003-02       Impact factor: 5.306

7.  MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data.

Authors:  Matthieu Bui Nguyen Binh; Xavier Sastre-Garau; Louis Guillou; Gonzague de Pinieux; Philippe Terrier; Réal Lagacé; Alain Aurias; Isabelle Hostein; Jean Michel Coindre
Journal:  Am J Surg Pathol       Date:  2005-10       Impact factor: 6.394

8.  Ovarian endometrioid adenocarcinoma with ectopic production of alpha-fetoprotein.

Authors:  Y Maida; S Kyo; M Takakura; T Kanaya; M Inoue
Journal:  Gynecol Oncol       Date:  1998-10       Impact factor: 5.482

9.  Alpha-fetoprotein-producing adenocarcinoma of the sigmoid colon with possible hepatoid differentiation.

Authors:  G R Hocking; M Shembrey; D Hay; A G Ostör
Journal:  Pathology       Date:  1995-07       Impact factor: 5.306

Review 10.  Neoplasms associated with paraneoplastic pemphigus: a review with emphasis on non-hematologic malignancy and oral mucosal manifestations.

Authors:  Ilana Kaplan; Emmilia Hodak; Lehavit Ackerman; Daniel Mimouni; Grant J Anhalt; Shlomo Calderon
Journal:  Oral Oncol       Date:  2004-07       Impact factor: 5.337
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  2 in total

1.  Paraneoplastic Syndrome Associated with the Retroperitoneal Dedifferentiated Liposarcoma: an Atypical Presentation and Review of the Literature.

Authors:  Jeewan Ram Vishnoi; Ankit Jain; Sanjeev Misra; Puneet Pareek; Meenakshi Rao; Binit Sureka; Ashok Puranik
Journal:  Indian J Surg Oncol       Date:  2019-08-13

2.  Retroperitoneal liposarcoma associated with small plaque parapsoriasis.

Authors:  Francesco Tartaglia; Sara Blasi; Monica Sgueglia; Paolo Polichetti; Luciana Tromba; Alberto Berni
Journal:  World J Surg Oncol       Date:  2007-07-09       Impact factor: 2.754
  2 in total

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