G Ottaviani1, L Matturri, R Mingrone, A M Lavezzi. 1. Institute of Pathology, Lino Rossi Research Centre for the study and prevention of unexpected perinatal death and SIDS, University of Milan, Italy. giulia.ottaviani@unimi.it
Abstract
OBJECTIVE: To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death. METHODS: Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem. RESULTS: Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus. CONCLUSIONS: Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.
OBJECTIVE: To report the case of five month old female baby with a history of episodes of gastro-oesophageal reflux and pneumonia. Her sudden death offered a unique insight into the possible role of delayed neuronal maturation and hypoplasia of the hypoglossal nucleus in representing a likely morphological substrate of sudden death. METHODS: Morphometric analysis was carried out with an Image-Pro Plus Image analyser (Media Cybernetics) on both sides of the brain stem. RESULTS:Hypoplasia and neuronal immaturity of the hypoglossal nucleus were demonstrated, accompanied by hypoplasia of the arcuate nucleus. CONCLUSIONS: Much attention should be paid to the possible role of the hypoglossal nucleus in determining a lethal outcome in infancy through impairment of deglutition and subsequent recurrent episodes of pneumonia, and as a necropsy finding.
Authors: Luigi Matturri; Giulia Ottaviani; Giulio Benedetti; Emanuela Agosta; Anna Maria Lavezzi Journal: Am J Forensic Med Pathol Date: 2005-06 Impact factor: 0.921
Authors: Luigi Matturri; Giulia Ottaviani; Graziella Alfonsi; Marina Crippa; Lino Rossi; Anna M Lavezzi Journal: Am J Forensic Med Pathol Date: 2004-03 Impact factor: 0.921
Authors: Henry F Krous; J Bruce Beckwith; Roger W Byard; Torleiv O Rognum; Thomas Bajanowski; Tracey Corey; Ernest Cutz; Randy Hanzlick; Thomas G Keens; Edwin A Mitchell Journal: Pediatrics Date: 2004-07 Impact factor: 7.124