T Y Wong1, Q Mohamed, R Klein, D J Couper. 1. Retinal Vascular Imaging Centre, Centre for Eye Research Australia, Univeristy of Melbourne, 32 Gisborne Street, VIC 3002, Australia. twong@unimelb.edu.au
Abstract
BACKGROUND/AIMS: Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined. METHODS: A population based cohort study of 7992 people aged 49-73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively. RESULTS: After a follow up of 3 years, 291 (3.6%) people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes (4.7% v 3.6%, multivariable adjusted odds ratio (OR) 1.1, 95% confidence intervals (CI), 0.7 to 1.9). However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes (10.4% v 4.8%, multivariable adjusted OR 2.3, 95% CI, 1.0 to 5.3). Among participants without a family history of diabetes, retinopathy was not associated with incident diabetes CONCLUSIONS: In individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes.
BACKGROUND/AIMS: Isolated retinopathy signs are common in non-diabetic individuals and have been shown to be associated with impaired glucose metabolism. In a cohort of people without diabetes, the association of these retinopathy signs and subsequent development of diabetes were examined. METHODS: A population based cohort study of 7992 people aged 49-73 years without diabetes was conducted. Retinal photographs of these participants were evaluated for the presence of retinopathy signs according to a standardised protocol. Incident cases of diabetes were identified prospectively. RESULTS: After a follow up of 3 years, 291 (3.6%) people developed incident diabetes. In the total cohort, retinopathy was not significantly associated with incident diabetes (4.7% v 3.6%, multivariable adjusted odds ratio (OR) 1.1, 95% confidence intervals (CI), 0.7 to 1.9). However, among participants with a positive family history of diabetes, retinopathy was associated with incident diabetes (10.4% v 4.8%, multivariable adjusted OR 2.3, 95% CI, 1.0 to 5.3). Among participants without a family history of diabetes, retinopathy was not associated with incident diabetes CONCLUSIONS: In individuals with a family history of diabetes, retinopathy signs predict subsequent risk of clinical diabetes.
Authors: Tien Yin Wong; Ronald Klein; A Richey Sharrett; Teri A Manolio; Larry D Hubbard; Emily K Marino; Lewis Kuller; Gregory Burke; Russell P Tracy; Joseph F Polak; John S Gottdiener; David S Siscovick Journal: Ophthalmology Date: 2003-04 Impact factor: 12.079
Authors: T Y Wong; R Klein; D J Couper; L S Cooper; E Shahar; L D Hubbard; M R Wofford; A R Sharrett Journal: Lancet Date: 2001-10-06 Impact factor: 79.321
Authors: Tien Yin Wong; Ronald Klein; A Richey Sharrett; Maria I Schmidt; James S Pankow; David J Couper; Barbara E K Klein; Larry D Hubbard; Bruce B Duncan Journal: JAMA Date: 2002-05-15 Impact factor: 56.272
Authors: Tien Yin Wong; Bruce B Duncan; Sherita Hill Golden; Ronald Klein; David J Couper; Barbara E K Klein; Larry D Hubbard; A Richey Sharrett; Maria I Schmidt Journal: Invest Ophthalmol Vis Sci Date: 2004-09 Impact factor: 4.799
Authors: Ronald Klein; A Richey Sharrett; Barbara E K Klein; Scot E Moss; Aaron R Folsom; Tien Y Wong; Frederick L Brancati; Larry D Hubbard; David Couper Journal: Ophthalmology Date: 2002-07 Impact factor: 12.079
Authors: Elvis Ojaimi; Thanh T Nguyen; Ronald Klein; F M Amirul Islam; Mary Frances Cotch; Barbara E K Klein; Jie-Jin Wang; Tien Yin Wong Journal: Ophthalmology Date: 2010-11-04 Impact factor: 12.079
Authors: Yash R Patel; M Sue Kirkman; Robert V Considine; Tamara S Hannon; Kieren J Mather Journal: J Diabetes Complications Date: 2016-11-12 Impact factor: 2.852
Authors: Joanne Wen Yee Yau; Jing Xie; Ecosse Lamoureux; Ronald Klein; Barbara E K Klein; Mary Frances Cotch; Alain G Bertoni; Steven Shea; Tien Y Wong Journal: Diabetes Res Clin Pract Date: 2011-11-15 Impact factor: 5.602
Authors: Tien Y Wong; Gerald Liew; Robyn J Tapp; Maria Inês Schmidt; Jie Jin Wang; Paul Mitchell; Ronald Klein; Barbara E K Klein; Paul Zimmet; Jonathan Shaw Journal: Lancet Date: 2008-03-01 Impact factor: 79.321
Authors: Elizabeth Selvin; Yang Ning; Michael W Steffes; Lori D Bash; Ronald Klein; Tien Y Wong; Brad C Astor; A Richey Sharrett; Frederick L Brancati; Josef Coresh Journal: Diabetes Date: 2010-10-26 Impact factor: 9.461
Authors: Richard A Jensen; Xueling Sim; Xiaohui Li; Mary Frances Cotch; M Kamran Ikram; Elizabeth G Holliday; Gudny Eiriksdottir; Tamara B Harris; Fridbert Jonasson; Barbara E K Klein; Lenore J Launer; Albert Vernon Smith; Eric Boerwinkle; Ning Cheung; Alex W Hewitt; Gerald Liew; Paul Mitchell; Jie Jin Wang; John Attia; Rodney Scott; Nicole L Glazer; Thomas Lumley; Barbara McKnight; Bruce M Psaty; Kent Taylor; Albert Hofman; Paulus T V M de Jong; Fernando Rivadeneira; Andre G Uitterlinden; Wan-Ting Tay; Yik Ying Teo; Mark Seielstad; Jianjun Liu; Ching-Yu Cheng; Seang-Mei Saw; Tin Aung; Santhi K Ganesh; Christopher J O'Donnell; Mike A Nalls; Kerri L Wiggins; Jane Z Kuo; Cornelia M van Duijn; Vilmundur Gudnason; Ronald Klein; David S Siscovick; Jerome I Rotter; E Shong Tai; Johannes Vingerling; Tien Y Wong Journal: PLoS One Date: 2013-02-05 Impact factor: 3.240