Literature DB >> 16488943

Corneal ulceration in South East Asia. I: a model for the prevention of bacterial ulcers at the village level in rural Bhutan.

K Getshen1, M Srinivasan, M P Upadhyay, B Priyadarsini, R Mahalaksmi, J P Whitcher.   

Abstract

AIM: To prove that antibiotic distribution by grassroots volunteer village health workers (VVHWs) in Bhutan is an effective and efficient public health intervention for the prevention of post-traumatic corneal ulceration.
METHODS: 55 villages in two districts in Bhutan were selected for the study. A defined population of 10 139 individuals was followed prospectively for 18 months by 31 VVHWs who were trained to identify post-traumatic corneal abrasions with fluorescein dye and a blue torch and to administer 1% chloramphenicol ointment three times a day for 3 days to the eyes of individuals who fulfilled the eligibility criteria.
RESULTS: During the 18 month period 135 individuals reported to VVHWs with an ocular injury and 115 were found to have a corneal abrasion. All 115 were treated with 1% chloramphenicol ointment three times a day for 3 days and all healed without sequelae
CONCLUSIONS: Corneal ulcers that occur following traumatic corneal abrasions can be effectively prevented, even in the setting of isolated rural conditions such as those that exist in villages in Bhutan, by using relatively simple preventative measures that local VVHWs can easily be taught to employ.

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Year:  2006        PMID: 16488943      PMCID: PMC1856957          DOI: 10.1136/bjo.2005.076083

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  10 in total

Review 1.  Prevention of corneal ulceration in the developing world.

Authors:  John P Whitcher; M Srinivasan; Madan P Upadhyay
Journal:  Int Ophthalmol Clin       Date:  2002

Review 2.  Measles blindness.

Authors:  Richard D Semba; Martin W Bloem
Journal:  Surv Ophthalmol       Date:  2004 Mar-Apr       Impact factor: 6.048

Review 3.  Epidemiology of corneal blindness in developing countries.

Authors:  G T Smith; H R Taylor
Journal:  Refract Corneal Surg       Date:  1991 Nov-Dec

4.  Corneal ulceration in the developing world--a silent epidemic.

Authors:  J P Whitcher; M Srinivasan
Journal:  Br J Ophthalmol       Date:  1997-08       Impact factor: 4.638

5.  Aetiology of suppurative corneal ulcers in Ghana and south India, and epidemiology of fungal keratitis.

Authors:  A K Leck; P A Thomas; M Hagan; J Kaliamurthy; E Ackuaku; M John; M J Newman; F S Codjoe; J A Opintan; C M Kalavathy; V Essuman; C A N Jesudasan; G J Johnson
Journal:  Br J Ophthalmol       Date:  2002-11       Impact factor: 4.638

6.  The Bhaktapur eye study: ocular trauma and antibiotic prophylaxis for the prevention of corneal ulceration in Nepal.

Authors:  M P Upadhyay; P C Karmacharya; S Koirala; D N Shah; S Shakya; J K Shrestha; H Bajracharya; C K Gurung; J P Whitcher
Journal:  Br J Ophthalmol       Date:  2001-04       Impact factor: 4.638

7.  Epidemiology and aetiological diagnosis of corneal ulceration in Madurai, south India.

Authors:  M Srinivasan; C A Gonzales; C George; V Cevallos; J M Mascarenhas; B Asokan; J Wilkins; G Smolin; J P Whitcher
Journal:  Br J Ophthalmol       Date:  1997-11       Impact factor: 4.638

Review 8.  Corneal blindness: a global perspective.

Authors:  J P Whitcher; M Srinivasan; M P Upadhyay
Journal:  Bull World Health Organ       Date:  2003-07-07       Impact factor: 9.408

Review 9.  Epidemiological patterns of ocular trauma.

Authors:  B Thylefors
Journal:  Aust N Z J Ophthalmol       Date:  1992-05

10.  Epidemiologic characteristics, predisposing factors, and etiologic diagnosis of corneal ulceration in Nepal.

Authors:  M P Upadhyay; P C Karmacharya; S Koirala; N R Tuladhar; L E Bryan; G Smolin; J P Whitcher
Journal:  Am J Ophthalmol       Date:  1991-01-15       Impact factor: 5.258

  10 in total
  21 in total

Review 1.  The persistent dilemma of microbial keratitis: Global burden, diagnosis, and antimicrobial resistance.

Authors:  Lawson Ung; Paulo J M Bispo; Swapna S Shanbhag; Michael S Gilmore; James Chodosh
Journal:  Surv Ophthalmol       Date:  2018-12-24       Impact factor: 6.048

2.  Corneal ulceration in south-east Asia III: prevention of fungal keratitis at the village level in south India using topical antibiotics.

Authors:  M Srinivasan; M P Upadhyay; B Priyadarsini; R Mahalakshmi; J P Whitcher
Journal:  Br J Ophthalmol       Date:  2006-08-17       Impact factor: 4.638

3.  Novel Image-Based Analysis for Reduction of Clinician-Dependent Variability in Measurement of the Corneal Ulcer Size.

Authors:  Tapan P Patel; N Venkatesh Prajna; Sina Farsiu; Nita G Valikodath; Leslie M Niziol; Lakshey Dudeja; Kyeong Hwan Kim; Maria A Woodward
Journal:  Cornea       Date:  2018-03       Impact factor: 2.651

4.  Corneal ulceration in South East Asia. II: a strategy for the prevention of fungal keratitis at the village level in Burma.

Authors:  N Maung; C C Thant; M Srinivasan; M P Upadhyay; B Priyadarsini; R Mahalakshmi; J P Whitcher
Journal:  Br J Ophthalmol       Date:  2006-05-17       Impact factor: 4.638

Review 5.  Antibiotic prophylaxis for corneal abrasion.

Authors:  Abdullah M Algarni; Gordon H Guyatt; Angus Turner; Saad Alamri
Journal:  Cochrane Database Syst Rev       Date:  2022-05-27

6.  Managing corneal disease: focus on suppurative keratitis.

Authors:  Madan P Upadhyay; Muthiah Srinivasan; John P Whitcher
Journal:  Community Eye Health       Date:  2009-12

7.  Infectious keratitis in Vietnam: etiology, organisms, and management at Vietnam National Eye Hospital.

Authors:  Pham Ngoc Dong; Do Thi Thuy Hang; Nguyen Thi Nga Duong; Mai Thi Lien; Angela C Chen; Anthony J Aldave
Journal:  Int J Ophthalmol       Date:  2022-01-18       Impact factor: 1.779

8.  Diagnosing and managing microbial keratitis.

Authors:  Madan P Upadhyay; Muthiah Srinivasan; John P Whitcher
Journal:  Community Eye Health       Date:  2015

9.  A multi-center, cross-sectional study on the burden of infectious keratitis in China.

Authors:  Xiusheng Song; Lixin Xie; Xiaodong Tan; Zhichong Wang; Yanning Yang; Yuansheng Yuan; Yingping Deng; Shaoying Fu; Jianjiang Xu; Xuguang Sun; Xunlun Sheng; Qing Wang
Journal:  PLoS One       Date:  2014-12-01       Impact factor: 3.240

10.  Prevention of traumatic corneal ulcer in South East Asia.

Authors:  M Srinivasan
Journal:  Community Eye Health       Date:  2017
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