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Literature DB >> 1648889

Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice.

R H Gelber¹, P Siu, M Tsang, L P Murray.

Abstract

We evaluated the activities of several macrolide antibiotics against M. leprae infections in mouse footpads. Erythromycin and azithromycin were inactive, while both roxithromycin and clarithromycin were found to be consistently active and, in fact, bactericidal. By both methods, clarithromycin was found to be superior to roxithromycin, a finding which, at least in part, may be a consequence of the higher levels of clarithromycin at the site of infection.

Entities: Chemical Disease Species

Mesh：

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Year: 1991 PMID： 1648889 PMCID： PMC245094 DOI： 10.1128/AAC.35.4.760

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

20 in total

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4. Bioassay for A-56268 (TE-031) and identification of its major metabolite, 14-hydroxy-6-O-methyl erythromycin.

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5. Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity.

Authors: E B Harris; S G Franzblau; R C Hastings
Journal: Int J Lepr Other Mycobact Dis Date: 1988-12

6. In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.

Authors: N Ramasesh; J L Krahenbuhl; R C Hastings
Journal: Antimicrob Agents Chemother Date: 1989-05 Impact factor: 5.191

7. Rapid in vitro metabolic screen for antileprosy compounds.

Authors: S G Franzblau; R C Hastings
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8. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.

Authors: A E Girard; D Girard; A R English; T D Gootz; C R Cimochowski; J A Faiella; S L Haskell; J A Retsema
Journal: Antimicrob Agents Chemother Date: 1987-12 Impact factor: 5.191

9. Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium.

Authors: S G Franzblau
Journal: J Clin Microbiol Date: 1988-01 Impact factor: 5.948

10. In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide.

Authors: P B Fernandes; R Bailer; R Swanson; C W Hanson; E McDonald; N Ramer; D Hardy; N Shipkowitz; R R Bower; E Gade
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11 in total

Review 1. Hansen's disease.

Authors: R H Gelber
Journal: West J Med Date: 1993-06

2. The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently.

Authors: Robert Gelber; Koen Andries; Rose Maria D Paredes; Cora Evelyn S Andaya; Jasmin Burgos
Journal: Antimicrob Agents Chemother Date: 2009-07-13 Impact factor: 5.191

Activities of various macrolide antibiotics against Mycobacterium leprae infection in mice.

Review 1. Progress in the chemotherapy of leprosy: status, issues and prospects.

2. Activity of minocycline in Mycobacterium leprae-infected mice.

3. Kinetic testing of drugs against Mycobacterium leprae in mice. Activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin.

4. Bioassay for A-56268 (TE-031) and identification of its major metabolite, 14-hydroxy-6-O-methyl erythromycin.

5. Inhibition of phenolic glycolipid-I synthesis in extracellular Mycobacterium leprae as an indicator of antimicrobial activity.

6. In vitro effects of antimicrobial agents on Mycobacterium leprae in mouse peritoneal macrophages.

7. Rapid in vitro metabolic screen for antileprosy compounds.

8. Pharmacokinetic and in vivo studies with azithromycin (CP-62,993), a new macrolide with an extended half-life and excellent tissue distribution.

9. Oxidation of palmitic acid by Mycobacterium leprae in an axenic medium.

10. In vitro and in vivo evaluation of A-56268 (TE-031), a new macrolide.

Review 1. Hansen's disease.

2. The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently.

Review 3. Choosing the right macrolide antibiotic. A guide to selection.

4. Clinical trial of clarithromycin for lepromatous leprosy.

5. Activities of various quinolone antibiotics against Mycobacterium leprae in infected mice.

Review 6. Chemotherapy of lepromatous leprosy: recent developments and prospects for the future.

7. Activities of azithromycin and clarithromycin against nontuberculous mycobacteria in beige mice.

Review 8. Azithromycin. A review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy.

Review 9. Clarithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential.

Review 10. Roxithromycin. An update of its antimicrobial activity, pharmacokinetic properties and therapeutic use.