Literature DB >> 1648888

Pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-deoxy-2',3'-didehydrothymidine in rats.

F D Boudinot1, S G Smith, E D Funderburg, R F Schinazi.   

Abstract

Concentrations of 3'-fluoro-3'-deoxythymidine (FDT) and 3'-deoxy-2',3'-didehydrothymidine (D4T) in plasma declined in a biexponential fashion. Total clearance of D4T (1.75 +/- 0.22 liters/h/kg; mean +/- standard deviation) was significantly greater than that of FDT (1.19 +/- 0.19 liters/h/kg) owing to greater renal and nonrenal clearances of the former. Steady-state volumes of distribution of FDT (1.20 +/- 0.12 liters/kg) and D4T (1.07 +/- 0.15 liters/kg) were similar.

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Year:  1991        PMID： 1648888      PMCID： PMC245090          DOI： 10.1128/AAC.35.4.747

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  Dose-ranging pharmacokinetics of zidovudine (azidothymidine) in the rat.

Authors:  J D Unadkat; J P Wang; D Pulham; R L Semmes
Journal:  Pharm Res       Date:  1989-08       Impact factor: 4.200

2.  Analytical method for the quantification of 2',3'-didehydro-3'-deoxythymidine, a new anti-human immunodeficiency virus (HIV) agent, by high-performance liquid chromatography (HPLC) and ultraviolet (UV) detection in rat and monkey plasma.

Authors:  S Kaul; K A Dandekar; K A Pittman
Journal:  Pharm Res       Date:  1989-10       Impact factor: 4.200

3.  Potent and selective in vitro activity of 3'-deoxythymidin-2'-ene (3'-deoxy-2',3'-didehydrothymidine) against human immunodeficiency virus.

Authors:  T S Lin; R F Schinazi; W H Prusoff
Journal:  Biochem Pharmacol       Date:  1987-09-01       Impact factor: 5.858

4.  An analysis of the inhibition of replication of HIV and MuLV by some 3'-blocked pyrimidine analogs.

Authors:  H Bazin; J Chattopadhyaya; R Datema; A C Ericson; G Gilljam; N G Johansson; J Hansen; R Koshida; K Moelling; B Oberg
Journal:  Biochem Pharmacol       Date:  1989-01-01       Impact factor: 5.858

5.  Statistical estimations in pharmacokinetics.

Authors:  H G Boxenbaum; S Riegelman; R M Elashoff
Journal:  J Pharmacokinet Biopharm       Date:  1974-04

6.  Inhibitory effect of 2',3'-didehydro-2',3'-dideoxynucleosides on infectivity, cytopathic effects, and replication of human immunodeficiency virus.

Authors:  Y Hamamoto; H Nakashima; T Matsui; A Matsuda; T Ueda; N Yamamoto
Journal:  Antimicrob Agents Chemother       Date:  1987-06       Impact factor: 5.191

7.  Both 2',3'-dideoxythymidine and its 2',3'-unsaturated derivative (2',3'-dideoxythymidinene) are potent and selective inhibitors of human immunodeficiency virus replication in vitro.

Authors:  M Baba; R Pauwels; P Herdewijn; E De Clercq; J Desmyter; M Vandeputte
Journal:  Biochem Biophys Res Commun       Date:  1987-01-15       Impact factor: 3.575

8.  Potent and selective anti-HTLV-III/LAV activity of 2',3'-dideoxycytidinene, the 2',3'-unsaturated derivative of 2',3'-dideoxycytidine.

Authors:  J Balzarini; R Pauwels; P Herdewijn; E De Clercq; D A Cooney; G J Kang; M Dalal; D G Johns; S Broder
Journal:  Biochem Biophys Res Commun       Date:  1986-10-30       Impact factor: 3.575

9.  1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent.

Authors:  M M Mansuri; J E Starrett; I Ghazzouli; M J Hitchcock; R Z Sterzycki; V Brankovan; T S Lin; E M August; W H Prusoff; J P Sommadossi
Journal:  J Med Chem       Date:  1989-02       Impact factor: 7.446

10.  Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides.

Authors:  P Herdewijn; J Balzarini; M Baba; R Pauwels; A Van Aerschot; G Janssen; E De Clercq
Journal:  J Med Chem       Date:  1988-10       Impact factor: 7.446
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  5 in total

1.  Microdialysis studies of the distribution of stavudine into the central nervous system in the freely-moving rat.

Authors:  Z Yang; R C Brundage; R H Barbhaiya; R J Sawchuk
Journal:  Pharm Res       Date:  1997-07       Impact factor: 4.200

2.  Synthesis and Biological Evaluation of 5'-O-Fatty Acyl Ester Derivatives of 3'-Fluoro-2',3'-dideoxythymidine as Potential Anti-HIV Microbicides.

Authors:  Hitesh K Agarwal; Bhupender S Chhikara; Guofeng Ye; Sitaram Bhavaraju; Ajay Dixit; Anil Kumar; Gustavo F Doncel; Keykavous Parang
Journal:  Molecules       Date:  2022-05-23       Impact factor: 4.927

3.  Pharmacokinetics of the anti-human immunodeficiency virus nucleoside analog stavudine in cynomolgus monkeys.

Authors:  S Kaul; K A Dandekar
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

4.  Pharmacokinetics, oral bioavailability, and metabolic disposition in rats of (-)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analog active against human immunodeficiency virus and hepatitis B virus.

Authors:  L W Frick; L St John; L C Taylor; G R Painter; P A Furman; D C Liotta; E S Furfine; D J Nelson
Journal:  Antimicrob Agents Chemother       Date:  1993-11       Impact factor: 5.191

5.  Comparisons of anti-human immunodeficiency virus activities, cellular transport, and plasma and intracellular pharmacokinetics of 3'-fluoro-3'-deoxythymidine and 3'-azido-3'-deoxythymidine.

Authors:  X B Kong; Q Y Zhu; P M Vidal; K A Watanabe; B Polsky; D Armstrong; M Ostrander; S A Lang; E Muchmore; T C Chou
Journal:  Antimicrob Agents Chemother       Date:  1992-04       Impact factor: 5.191
  5 in total

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