Literature DB >> 1648845

Ultrastructural abnormalities of mitochondria and deficiency of myocardial cytochrome c oxidase in a patient with ventricular tachycardia.

B Schwartzkopff1, S Zierz, H Frenzel, M Block, E Neuen-Jacob, K Reiners, B E Strauer.   

Abstract

A 30-year-old woman presented with life-threatening ventricular tachycardia without overt heart disease. Ultrastructural investigation of endomyocardial biopsy disclosed abnormally structured and often enlarged mitochondria. Morphometry revealed the ratio of volume density of mitochondria to myofibrils to be markedly increased to 0.667 as compared with five controls (mean: 0.46; range: 0.445-0.479). Investigation of mitochondrial respiratory chain enzymes revealed a 90% reduction in activity of cytochrome c oxidase. Our data suggest that mitochondrial cardiomyopathy may induce malignant ventricular arrhythmias.

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Year:  1991        PMID： 1648845     DOI： 10.1007/bf01600154

Source DB:  PubMed          Journal:  Virchows Arch A Pathol Anat Histopathol        ISSN： 0174-7398


  28 in total

Review 1.  Cytochrome oxidase deficiency: clinical and biochemical heterogeneity.

Authors:  S DiMauro; M Zeviani; S Servidei; E Bonilla; A F Miranda; A Prelle; E A Schon
Journal:  Ann N Y Acad Sci       Date:  1986       Impact factor: 5.691

2.  Ultrastructural features of familial cardiomyopathy.

Authors:  P M Urie; M E Billingham
Journal:  Am J Cardiol       Date:  1988-08-01       Impact factor: 2.778

3.  Fatal mitochondrial cardiomyopathy in Kearns-Sayre syndrome with deficiency of cytochrome-c-oxidase in cardiac and skeletal muscle. An enzymehistochemical--ultra-immunocytochemical--fine structural study in longterm frozen autopsy tissue.

Authors:  J Müller-Höcker; A Johannes; M Droste; B Kadenbach; D Pongratz; G Hübner
Journal:  Virchows Arch B Cell Pathol Incl Mol Pathol       Date:  1986

4.  Ultrastructural findings in endomyocardial biopsy of patients with Kearns-Sayre syndrome.

Authors:  B Schwartzkopff; H Frenzel; G Breithardt; M Deckert; B Lösse; K V Toyka; M Borggrefe; W Hort
Journal:  J Am Coll Cardiol       Date:  1988-12       Impact factor: 24.094

5.  Friedreich's disease: a metabolic cardiomyopathy.

Authors:  D A Stumpf
Journal:  Am Heart J       Date:  1982-10       Impact factor: 4.749

Review 6.  Molecular defects in cytochrome oxidase in mitochondrial diseases.

Authors:  S DiMauro; M Zeviani; R Rizzuto; A Lombes; H Nakase; E Bonilla; A Miranda; E Schon
Journal:  J Bioenerg Biomembr       Date:  1988-06       Impact factor: 2.945

7.  Coenzyme Q in serum and muscle of 5 patients with Kearns-Sayre syndrome and 12 patients with ophthalmoplegia plus.

Authors:  S Zierz; G Jahns; F Jerusalem
Journal:  J Neurol       Date:  1989-02       Impact factor: 4.849

8.  An X-linked recessive cardiomyopathy with abnormal mitochondria.

Authors:  H B Neustein; P R Lurie; B Dahms; M Takahashi
Journal:  Pediatrics       Date:  1979-07       Impact factor: 7.124

9.  Variability and reproducibility of morphologic findings in endomyocardial biopsies of patients with hypertrophic obstructive cardiomyopathy.

Authors:  B Schwartzkopff; B Uhre; B Ehle; B Lösse; H Frenzel
Journal:  Z Kardiol       Date:  1987

10.  Ultrastructural morphometric analysis of myocardium from dogs, rats, hamsters, mice, and from human hearts.

Authors:  J Schaper; E Meiser; G Stämmler
Journal:  Circ Res       Date:  1985-03       Impact factor: 17.367
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  1 in total

1.  Homocysteine induces cardiac hypertrophy by up-regulating ATP7a expression.

Authors:  Zhanwei Cao; Yanzhou Zhang; Tongwen Sun; Shuguang Zhang; Weiya Yu; Jie Zhu
Journal:  Int J Clin Exp Pathol       Date:  2015-10-01
  1 in total

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