| Literature DB >> 16487721 |
Gilles Lambert1, Michel Krempf, Philippe Costet.
Abstract
PCSK9 is the third gene to be implicated in autosomal dominant hypercholesterolemia. The recent discovery of mutations in PCSK9 protein associated with low plasma low-density lipoprotein in humans, the characterization of PCSK9-deficient mice hypersensitive to statins and the severely pathological phenotype of D374Y PCSK9-mutated patients shed a new light on this gene: is it a promising therapeutic target for dyslipidemias?Entities:
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Year: 2006 PMID： 16487721 DOI： 10.1016/j.tem.2006.02.001
Source DB: PubMed Journal: Trends Endocrinol Metab ISSN： 1043-2760 Impact factor: 12.015