Literature DB >> 16487662

Control of hypertrophic scar from inception by using xenogenic (porcine) acellular dermal matrix (ADM) to cover deep second degree burn.

Xiangsheng Feng1, Jiaju Tan, Yingen Pan, Qiuhe Wu, Shubin Ruan, Rui Shen, Xiaodong Chen, Yongjun Du.   

Abstract

OBJECTIVE: We have spent 7 years to investigate the method of applying porcine acellular dermal matrix (ADM) on deep partial thickness burn wound until the wound heals without dressing change. Known as "Feng's pig skin method" by our hospital, the method appears to encourage rapid re-epithilization with minimum scarring.
METHOD: The deep partial thickness burn wound was rinsed cleanly under anesthesia when the patient admitted. ADM was applied on the wound after the detached epidermis was thoroughly removed, wrapped and fixed by sterile gauze and bandages. The dressing was removed within two weeks and the wound completely healed. The outcome of the treatment was analyzed by using the modified Vancouver Burn Scar Assessment Scale. RESULT: All the wounds healed with one dressing within 2 weeks, and the time of wound re-epithelialization shortened to 7-12 days. Scar hyperplasia did not occur, or it was greatly ameliorated compared with traditional treatment after a followed-up period of 3 months to 2 years. The Scar Index was significant lower than that of the traditional exposure method.
CONCLUSION: Using ADM to cover deep second degree burn can preserve maximally residual dermal tissue and epithelium, help accelerate the regeneration of epithelial and stem cells, thus shorten the healing time, remodel the skin structure, and consequently has the effect of controlling hypertrophic scar at inception.

Entities:  

Mesh:

Year:  2006        PMID: 16487662     DOI: 10.1016/j.burns.2005.10.006

Source DB:  PubMed          Journal:  Burns        ISSN: 0305-4179            Impact factor:   2.744


  10 in total

Review 1.  Cell colonization in degradable 3D porous matrices.

Authors:  Benjamin J Lawrence; Sundararajan V Madihally
Journal:  Cell Adh Migr       Date:  2008-01-08       Impact factor: 3.405

2.  The effect of porcine ADM to improve the burn wound healing.

Authors:  Xiaodong Chen; Yan Shi; Bin Shu; Xiaoxia Xie; Ronghua Yang; Lijun Zhang; Shubin Ruan; Yan Lin; Zepeng Lin; Rui Shen; Fenggang Zhang; Xiangsheng Feng; Julin Xie
Journal:  Int J Clin Exp Pathol       Date:  2013-10-15

3.  Effects of porcine acellular dermal matrix treatment on wound healing and scar formation: Role of Jag1 expression in epidermal stem cells.

Authors:  Xiao-Dong Chen; Shu-Bin Ruan; Ze-Peng Lin; Ziheng Zhou; Feng-Gang Zhang; Rong-Hua Yang; Ju-Lin Xie
Journal:  Organogenesis       Date:  2018-04-27       Impact factor: 2.500

4.  In situ scarless skin healing of a severe human burn wound induced by a hCTLA4Ig gene-transferred porcine skin graft.

Authors:  Lijun Zhang; Guangchao Xu; Yating Wei; Mingzhou Yuan; Yuanyuan Li; Meifang Yin; Chufen Chen; Guangtao Huang; Bin Shu; Jun Wu
Journal:  Int J Med Sci       Date:  2022-05-21       Impact factor: 3.642

5.  Human keratinocyte growth and differentiation on acellular porcine dermal matrix in relation to wound healing potential.

Authors:  Robert Zajicek; Vaclav Mandys; Ondrej Mestak; Jan Sevcik; Radana Königova; Eva Matouskova
Journal:  ScientificWorldJournal       Date:  2012-05-03

6.  Report of an unusually large, surgically excised squamous cell carcinoma successfully treated with porcine transitional epithelium.

Authors:  Robert Bacigalupi; Hooman Khorasani
Journal:  JAAD Case Rep       Date:  2015-06-13

Review 7.  Decellularized scaffolds in regenerative medicine.

Authors:  Yaling Yu; Ali Alkhawaji; Yuqiang Ding; Jin Mei
Journal:  Oncotarget       Date:  2016-09-06

8.  Introduction of a New Surgical Method to Improve Bone Healing in a Large Bone Defect by Replacement of the Induced Membrane by a Human Decellularized Dermis Repopulated with Bone Marrow Mononuclear Cells in Rat.

Authors:  Maximilian Leiblein; Tobias Kolb; Lion Christian; Katrin Schröder; Ceyhan Yaman; Alexander Schaible; Ingo Marzi; Dirk Henrich; Maren Janko
Journal:  Materials (Basel)       Date:  2020-06-09       Impact factor: 3.623

9.  Xenogenic (porcine) acellular dermal matrix is useful for the wound healing of severely damaged extremities.

Authors:  Zhaoxin Zhang; Lei Lv; Masut Mamat; Zhao Chen; Lihua Liu; Zhizhong Wang
Journal:  Exp Ther Med       Date:  2014-01-20       Impact factor: 2.447

10.  A novel dermal matrix generated from burned skin as a promising substitute for deep-degree burns therapy.

Authors:  Guanying Yu; Lan Ye; Wei Tan; Xuguo Zhu; Yaonan Li; Duyin Jiang
Journal:  Mol Med Rep       Date:  2016-02-04       Impact factor: 2.952

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.