"I won't do what you tell me!": elevated mood and the assessment of advice-taking in euthymic bipolar I disorder.

We hypothesized that when individuals with bipolar disorder are engaged in goal-directed behaviour and experience elevated mood, their decision-making becomes less constrained by advice from other people. This process may allow their goal-directed behaviour to persist, contributing to manic symptoms. Three groups of 32 participants: euthymic-bipolar-I, remitted-unipolar and never-depressed healthy controls were allocated to either a high or low mood induction. Advice-taking was assessed before and after the induction by a computerized task incorporating facial images. The bipolar group significantly opposed the advice given in the task after the high mood induction. The effect was specific to bipolar disorder and remained when controlling for possible confounds. Future work could investigate the effects of this process on manic symptoms, its origins, and the wider theoretical and clinical implications.

RCT Entities:   Population Interventions Outcomes