AIMS: To report nine additional well-defined cases with infiltrative myelopathy by paracoccidioidomycosis (PCM), to describe the specific lesions and infection-related stromal abnormalities, to review the literature on this type of involvement and to introduce a new cause of granulomatous lesions of bone marrow. METHODS AND RESULTS: Different bone marrow specimens were studied (aspirated smears, aspirated clots, biopsy imprints and biopsies) from nine patients with acute or subacute forms of PCM known to have PCM infiltrative myelopathy. CONCLUSIONS: The biopsy specimens were the best for demonstrating bone marrow involvement by PCM. The lesions varied from compact and focal granulomas with few fungal cells to numerous disseminated fungal cells within a loose granulomatous inflammatory reaction, with a continuum between these extremes suggesting a spectrum of immune response to the fungi. Other findings such as bone marrow fibrosis, parenchymal coagulative necrosis and bone necrosis were also observed in the affected areas.
AIMS: To report nine additional well-defined cases with infiltrative myelopathy by paracoccidioidomycosis (PCM), to describe the specific lesions and infection-related stromal abnormalities, to review the literature on this type of involvement and to introduce a new cause of granulomatous lesions of bone marrow. METHODS AND RESULTS: Different bone marrow specimens were studied (aspirated smears, aspirated clots, biopsy imprints and biopsies) from nine patients with acute or subacute forms of PCM known to have PCM infiltrative myelopathy. CONCLUSIONS: The biopsy specimens were the best for demonstrating bone marrow involvement by PCM. The lesions varied from compact and focal granulomas with few fungal cells to numerous disseminated fungal cells within a loose granulomatous inflammatory reaction, with a continuum between these extremes suggesting a spectrum of immune response to the fungi. Other findings such as bone marrow fibrosis, parenchymal coagulative necrosis and bone necrosis were also observed in the affected areas.
Authors: Silvio Alencar Marques; Joel Carlos Lastória; Rosangela Maria Pires de Camargo; Mariangela Esther Alencar Marques Journal: An Bras Dermatol Date: 2016 May-Jun Impact factor: 1.896
Authors: Juliano Júlio Cerci; Mateos Bogoni; Valeria Buccheri; Elba Cristina Sá de Camargo Etchebehere; Talita Maira Bueno da Silveira; Otavio Baiocchi; Carlos de Araujo Cunha Pereira Neto; Marcelo Tatit Sapienza; Jose Flavio Gomes Marin; José Cláudio Meneghetti; Yana Novis; Carmino Antonio de Souza; Carlos Chiattone; Marcia Torresan; Celso Dario Ramos Journal: Hematol Transfus Cell Ther Date: 2018-04-24
Authors: Lucilene S R Resende; Rinaldo P Mendes; Maura M Bacchi; Sílvio A Marques; Benedito Barraviera; Lenice R Souza; Domingos A Meira; Lígia Niéro-Melo Journal: Histopathology Date: 2009-03 Impact factor: 5.087