Literature DB >> 16487091

Cutaneous manifestations of granulocyte colony-stimulating factor.

J M L White1, G J Mufti, J R Salisbury, A W P du Vivier.   

Abstract

Granulocyte colony-stimulating factor (GCSF) is a recombinant human growth factor widely used in haematology. It is known to cause cutaneous vasculitis and neutrophilic dermatoses. We present three cases of Sweet's syndrome (SS) associated with GCSF use. Raised GCSF levels have been demonstrated in patients with SS. GCSF is the best understood mechanism by which neutrophil accumulation occurs and shows a dose-dependent effect in provoking SS.

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Year:  2006        PMID： 16487091     DOI： 10.1111/j.1365-2230.2005.01996.x

Source DB:  PubMed          Journal:  Clin Exp Dermatol        ISSN： 0307-6938            Impact factor:   3.470


  11 in total

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