| Literature DB >> 1648582 |
G B Baker1, J T Wong, J M Yeung, R T Coutts.
Abstract
Time- and dose-response studies were carried out on the effects of the monoamine oxidase-inhibiting antidepressant and antipanic drug phenelzine on GABA levels in rat whole brain. At a dose of 15 mg/kg i.p., phenelzine significantly elevated GABA levels at all time intervals studied (1, 2, 4, 8, 16, and 24 h). A further investigation indicated that this was a dose-dependent effect. The possible importance of GABA in the etiology and pharmacotherapy of depression and panic disorder is discussed.Entities:
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Year: 1991 PMID： 1648582 DOI： 10.1016/0165-0327(91)90041-p
Source DB: PubMed Journal: J Affect Disord ISSN： 0165-0327 Impact factor: 4.839