Literature DB >> 16484997

Between a rock and a hard place?

Adrian Whitty1, Gnanasambandam Kumaravel.   

Abstract

Developing small-molecule inhibitors against protein-protein interaction targets is among the most difficult challenges in contemporary drug discovery. Recent developments in our understanding of this problem, and in the knowledge and tools available to address it, give cause for renewed hope, but substantial challenges remain.

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Year:  2006        PMID： 16484997     DOI： 10.1038/nchembio0306-112

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  75 in total

Review 1.  Targeting Eph receptors with peptides and small molecules: progress and challenges.

Authors:  Roberta Noberini; Ilaria Lamberto; Elena B Pasquale
Journal:  Semin Cell Dev Biol       Date:  2011-10-25       Impact factor: 7.727

2.  Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.

Authors:  Brandon S Zerbe; David R Hall; Sandor Vajda; Adrian Whitty; Dima Kozakov
Journal:  J Chem Inf Model       Date:  2012-07-24       Impact factor: 4.956

3.  Medicinal chemistry for 2020.

Authors:  Seetharama D Satyanarayanajois; Ronald A Hill
Journal:  Future Med Chem       Date:  2011-10       Impact factor: 3.808

Review 4.  Small molecule inhibitors of amyloid β peptide aggregation as a potential therapeutic strategy for Alzheimer's disease.

Authors:  Qin Nie; Xiao-guang Du; Mei-yu Geng
Journal:  Acta Pharmacol Sin       Date:  2011-04-18       Impact factor: 6.150

5.  Design of protein membrane interaction inhibitors by virtual ligand screening, proof of concept with the C2 domain of factor V.

Authors:  Kenneth Segers; Olivier Sperandio; Markus Sack; Rainer Fischer; Maria A Miteva; Jan Rosing; Gerry A F Nicolaes; Bruno O Villoutreix
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-23       Impact factor: 11.205

6.  Lessons for fragment library design: analysis of output from multiple screening campaigns.

Authors:  I-Jen Chen; Roderick E Hubbard
Journal:  J Comput Aided Mol Des       Date:  2009-06-03       Impact factor: 3.686

Review 7.  G protein betagamma subunits as targets for small molecule therapeutic development.

Authors:  Alan V Smrcka; David M Lehmann; Axel L Dessal
Journal:  Comb Chem High Throughput Screen       Date:  2008-06       Impact factor: 1.339

8.  Identifying modulators of protein-protein interactions using photonic crystal biosensors.

Authors:  James T Heeres; Seok-Ho Kim; Benjamin J Leslie; Erich A Lidstone; Brian T Cunningham; Paul J Hergenrother
Journal:  J Am Chem Soc       Date:  2009-12-30       Impact factor: 15.419

9.  Non-peptidic thrombospondin-1 mimics as fibroblast growth factor-2 inhibitors: an integrated strategy for the development of new antiangiogenic compounds.

Authors:  Giorgio Colombo; Barbara Margosio; Laura Ragona; Marco Neves; Silvia Bonifacio; Douglas S Annis; Matteo Stravalaci; Simona Tomaselli; Raffaella Giavazzi; Marco Rusnati; Marco Presta; Lucia Zetta; Deane F Mosher; Domenico Ribatti; Marco Gobbi; Giulia Taraboletti
Journal:  J Biol Chem       Date:  2010-01-07       Impact factor: 5.157

10.  Differences between high- and low-affinity complexes of enzymes and nonenzymes.

Authors:  Heather A Carlson; Richard D Smith; Nickolay A Khazanov; Paul D Kirchhoff; James B Dunbar; Mark L Benson
Journal:  J Med Chem       Date:  2008-10-01       Impact factor: 7.446
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