| Literature DB >> 16484748 |
Taisuke Morimoto1, Takeo Sato, Akihiro Matsuoka, Tetsu Sakamoto, Keisuke Ohta, Tsunehiro Ando, Soichiro Ikushima, Kiyofumi Hagiwara, Hiroaki Matsuno, Osamu Akiyama, Masaru Oritsu.
Abstract
A 27-year-old man who had a history of bronchial asthma, eosinophilic enteritis, and eosinophilic pneumonia presented with fever, skin eruptions, cervical lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and eosinophilia two weeks after receiving trimethoprim (TMP)-sulfamethoxazole (SMX) treatment. After the withdrawal of TMP-SMX and the administration of high-dose steroid, these systemic symptoms gradually resolved. During the disease course, the patient showed a transient increase in anti-human herpesvirus (HHV)-6 antibody titers and HHV-6 DNA in the peripheral blood, indicating the reactivation of a latent HHV-6 infection. This is the first case of TMP-SMX-induced hypersensitivity syndrome associated with the reactivation of a latent viral infection.Entities:
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Year: 2006 PMID： 16484748 DOI： 10.2169/internalmedicine.45.1352
Source DB: PubMed Journal: Intern Med ISSN： 0918-2918 Impact factor: 1.271