Literature DB >> 16484581

Aged garlic extract protects against methotrexate-induced apoptotic cell injury of IEC-6 cells.

Toshiharu Horie1, Tiesong Li, Kousei Ito, Shin-ichiro Sumi, Toru Fuwa.   

Abstract

Gastrointestinal toxicity is one of the most serious side effects of methotrexate (MTX) treatment. The side effects often disrupt the cancer chemotherapy. We previously reported that aged garlic extract (AGE) protects the small intestine of rats from MTX-induced damage. In this study, the protection of AGE against MTX-induced damage of IEC-6 cells originating from the rat jejunum crypt was investigated. MTX decreased the viability of IEC-6 cells, but this effect was prevented by AGE (0.5%). The MTX-induced apoptosis of IEC-6 cells was depressed by AGE. These results indicated that AGE protects IEC-6 cells from the MTX-induced damage. AGE may be useful in cancer chemotherapy with MTX because it reduces MTX-induced intestinal damage.

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Year:  2006        PMID： 16484581     DOI： 10.1093/jn/136.3.861S

Source DB:  PubMed          Journal:  J Nutr        ISSN： 0022-3166            Impact factor:   4.798


  7 in total

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Journal:  PLoS One       Date:  2013-09-06       Impact factor: 3.240

7.  Screening of cytoprotectors against methotrexate-induced cytogenotoxicity from bioactive phytochemicals.

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Journal:  PeerJ       Date:  2016-05-11       Impact factor: 2.984
  7 in total

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