| Literature DB >> 16484498 |
Aryaman Shalizi1, Brice Gaudillière, Zengqiang Yuan, Judith Stegmüller, Takahiro Shirogane, Qingyuan Ge, Yi Tan, Brenda Schulman, J Wade Harper, Azad Bonni.
Abstract
Postsynaptic differentiation of dendrites is an essential step in synapse formation. We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex. A transcriptional repressor form of MEF2A that is sumoylated at lysine-403 promoted dendritic claw differentiation. Activity-dependent calcium signaling induced a calcineurin-mediated dephosphorylation of MEF2A at serine-408 and, thereby, promoted a switch from sumoylation to acetylation at lysine-403, which led to inhibition of dendritic claw differentiation. Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain.Entities:
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Year: 2006 PMID： 16484498 DOI： 10.1126/science.1122513
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728