BACKGROUND AND PURPOSE: The present standard for staging intervertebral disk degeneration is a discrete scale, consisting usually of 5 stages. The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of intervertebral disk degeneration. METHODS: We obtained images in 5 volunteers with a 3D fast spin-echo sequence modified for the purpose of calculating T2 relaxation times from multiple echoes in the echo train. Disks were classified on the basis of conventional criteria into one of the 5 stages of disk degeneration. Average T2 values were calculated for stage II, III, and V disks, which were identified in the volunteers. Differences between the disk levels were analyzed with analysis of variance and differences between stages tested with a Student t test with significance set at the 0.01 level. RESULTS: In the 5 volunteers, 20 stage II, 4 stage III, and a single stage V disk were found. Contour plots showed the highest T2 values in the nucleus pulposus near the vertebral endplates and lower T2 values in the intranuclear cleft region and peripheral annulus fibrosus. Average T2 values were significantly lower in the type III and V disks than in the normal disks. CONCLUSIONS: The study suggests that intervertebral disks can be characterized and classified accurately by means of T2 values. More studies are warranted to determine the range of T2 values for normal disks.
BACKGROUND AND PURPOSE: The present standard for staging intervertebral disk degeneration is a discrete scale, consisting usually of 5 stages. The purpose of this pilot study was to investigate the use of T2 measurements as a continuous measure of intervertebral disk degeneration. METHODS: We obtained images in 5 volunteers with a 3D fast spin-echo sequence modified for the purpose of calculating T2 relaxation times from multiple echoes in the echo train. Disks were classified on the basis of conventional criteria into one of the 5 stages of disk degeneration. Average T2 values were calculated for stage II, III, and V disks, which were identified in the volunteers. Differences between the disk levels were analyzed with analysis of variance and differences between stages tested with a Student t test with significance set at the 0.01 level. RESULTS: In the 5 volunteers, 20 stage II, 4 stage III, and a single stage V disk were found. Contour plots showed the highest T2 values in the nucleus pulposus near the vertebral endplates and lower T2 values in the intranuclear cleft region and peripheral annulus fibrosus. Average T2 values were significantly lower in the type III and V disks than in the normal disks. CONCLUSIONS: The study suggests that intervertebral disks can be characterized and classified accurately by means of T2 values. More studies are warranted to determine the range of T2 values for normal disks.
Authors: Siegfried Trattnig; David Stelzeneder; Sabine Goed; Michael Reissegger; Tallal C Mamisch; Tatjana Paternostro-Sluga; Michael Weber; Pavol Szomolanyi; Goetz H Welsch Journal: Eur Radiol Date: 2010-06-19 Impact factor: 5.315
Authors: Goetz Hannes Welsch; Siegfried Trattnig; Tatjana Paternostro-Sluga; Klaus Bohndorf; Sabine Goed; David Stelzeneder; Tallal Charles Mamisch Journal: Skeletal Radiol Date: 2010-09-28 Impact factor: 2.199
Authors: Alina Messner; David Stelzeneder; Stefan Trattnig; Götz H Welsch; Martina Schinhan; Sebastian Apprich; Martin Brix; Reinhard Windhager; Siegfried Trattnig Journal: Eur Spine J Date: 2016-11-24 Impact factor: 3.134
Authors: Yi-Xiang J Wang; Feng Zhao; James F Griffith; Greta S P Mok; Jason C S Leung; Anil T Ahuja; Jing Yuan Journal: Eur Radiol Date: 2012-08-04 Impact factor: 5.315
Authors: S A Nagy; I Juhasz; H Komaromy; K Pozsar; I Zsigmond; G Perlaki; G Orsi; A Schwarcz; N Walter; T Doczi; P Bogner Journal: Clin Neuroradiol Date: 2013-11-12 Impact factor: 3.649
Authors: Suzanne E L Detiger; Roderick M Holewijn; Roel J W Hoogendoorn; Barend J van Royen; Marco N Helder; Ferco H Berger; Joost P A Kuijer; Theo H Smit Journal: Eur Spine J Date: 2014-08-05 Impact factor: 3.134