Literature DB >> 16483925

Fatty acids and insulin resistance: a perfect storm.

Seung-Hoi Koo1, Marc Montminy.   

Abstract

VLDL levels are elevated in type II diabetes, where they contribute to the risk of coronary heart disease. A study by Wolfrum and Stoffel (2006) shows that the forkhead protein Foxa2 stimulates hepatic VLDL production in concert with the coactivator PGC-1beta and that insulin inhibits this process by inactivating Foxa2.

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Year:  2006        PMID： 16483925     DOI： 10.1016/j.molcel.2006.02.001

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  8 in total

1.  Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes.

Authors:  X-D Wan; W-B Yang; Y-Z Xia; J-F Wang; T Lu; X-M Wang
Journal:  J Endocrinol Invest       Date:  2009-04-29       Impact factor: 4.256

Review 2.  Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance.

Authors:  Sung Hee Choi; Henry N Ginsberg
Journal:  Trends Endocrinol Metab       Date:  2011-05-26       Impact factor: 12.015

Review 3.  Nitrotyrosine, Nitrated Lipoproteins, and Cardiovascular Dysfunction in Patients with Type 2 Diabetes: What Do We Know and What Remains to Be Explained?

Authors:  Grzegorz K Jakubiak; Grzegorz Cieślar; Agata Stanek
Journal:  Antioxidants (Basel)       Date:  2022-04-27

4.  Inhibition of protein kinase B by palmitate in the insulin signaling of HepG2 cells and the preventive effect of arachidonic acid on insulin resistance.

Authors:  Yanzhi Xia; Xuedong Wan; Qiuhong Duan; Shansu He; Ximing Wang
Journal:  Front Med China       Date:  2007-05-01

Review 5.  FoxO1 integrates insulin signaling to VLDL production.

Authors:  Adama Kamagate; H Henry Dong
Journal:  Cell Cycle       Date:  2008-10-27       Impact factor: 4.534

6.  Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice.

Authors:  Branislav Radović; Nemanja Vujić; Christina Leopold; Stefanie Schlager; Madeleine Goeritzer; Jay V Patankar; Melanie Korbelius; Dagmar Kolb; Julia Reindl; Martin Wegscheider; Tamara Tomin; Ruth Birner-Gruenberger; Matthias Schittmayer; Lukas Groschner; Christoph Magnes; Clemens Diwoky; Saša Frank; Ernst Steyrer; Hong Du; Wolfgang F Graier; Tobias Madl; Dagmar Kratky
Journal:  Diabetologia       Date:  2016-05-06       Impact factor: 10.122

7.  Attenuation of age-related metabolic dysfunction in mice with a targeted disruption of the Cbeta subunit of protein kinase A.

Authors:  Linda C Enns; John F Morton; Ruby Sue Mangalindan; G Stanley McKnight; Michael W Schwartz; Matt R Kaeberlein; Brian K Kennedy; Peter S Rabinovitch; Warren C Ladiges
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2009-09-23       Impact factor: 6.053

Review 8.  Nonalcoholic fatty liver disease: molecular mechanisms for the hepatic steatosis.

Authors:  Seung-Hoi Koo
Journal:  Clin Mol Hepatol       Date:  2013-09-30
  8 in total

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