Literature DB >> 16483924

The odyssey of k-ras.

Larry A Feig1.   

Abstract

A mechanism that regulates K-Ras signaling specificity by altering its subcellular location is presented by Bivona et al. (2006). Phosphorylation of its membrane-anchoring domain by PKC drives K-Ras off of the plasma membrane and onto the outer mitochondrial membrane where it induces cell death.

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Year:  2006        PMID: 16483924     DOI: 10.1016/j.molcel.2006.02.002

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  3 in total

1.  Oncogenic Ras and B-Raf proteins positively regulate death receptor 5 expression through co-activation of ERK and JNK signaling.

Authors:  You-Take Oh; Ping Yue; Wei Zhou; Justin M Balko; Esther P Black; Taofeek K Owonikoko; Fadlo R Khuri; Shi-Yong Sun
Journal:  J Biol Chem       Date:  2011-11-07       Impact factor: 5.157

2.  Subunit dissociation and diffusion determine the subcellular localization of rod and cone transducins.

Authors:  Derek H Rosenzweig; K Saidas Nair; Junhua Wei; Qiang Wang; Greg Garwin; John C Saari; Ching-Kang Chen; Alan V Smrcka; Anand Swaroop; Janis Lem; James B Hurley; Vladlen Z Slepak
Journal:  J Neurosci       Date:  2007-05-16       Impact factor: 6.167

3.  Multiple cellular proteins modulate the dynamics of K-ras association with the plasma membrane.

Authors:  Pinkesh Bhagatji; Rania Leventis; Rebecca Rich; Chen-ju Lin; John R Silvius
Journal:  Biophys J       Date:  2010-11-17       Impact factor: 4.033

  3 in total

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