| Literature DB >> 16483772 |
Alex G Waterson1, Kirk L Stevens, Michael J Reno, Yue-Mei Zhang, Eric E Boros, Frederic Bouvier, Abdullah Rastagar, David E Uehling, Scott H Dickerson, Bryan Reep, Octerloney B McDonald, Edgar R Wood, David W Rusnak, Krystal J Alligood, Sharon K Rudolph.
Abstract
Anilinoalkynylpyrimidines were prepared and evaluated as dual EGFR/ErbB2 kinase inhibitors. A preference was found for substituted phenyl and heteroaromatic rings attached to the alkyne. In addition, the presence of a potential hydrogen bond donor appended to this ring was favored. Selected molecules in the series demonstrated some activity against human tumor cell lines.Entities:
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Year: 2006 PMID： 16483772 DOI： 10.1016/j.bmcl.2006.01.111
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823