Literature DB >> 16483769

Low molecular weight indole fragments as IMPDH inhibitors.

Rebekah E Beevers1, George M Buckley, Natasha Davies, Joanne L Fraser, Francis C Galvin, Duncan R Hannah, Alan F Haughan, Kerry Jenkins, Stephen R Mack, William R Pitt, Andrew J Ratcliffe, Marianna D Richard, Verity Sabin, Andrew Sharpe, Sophie C Williams.   

Abstract

The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.

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Year:  2006        PMID: 16483769     DOI: 10.1016/j.bmcl.2006.01.089

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  Inhibitors of inosine 5'-monophosphate dehydrogenase as emerging new generation antimicrobial agents.

Authors:  Kapil Juvale; Althaf Shaik; Sivapriya Kirubakaran
Journal:  Medchemcomm       Date:  2019-05-02       Impact factor: 3.597

2.  Novel 3-aryl indoles as progesterone receptor antagonists for uterine fibroids.

Authors:  Timothy I Richardson; Christian A Clarke; Kuo-Long Yu; Ying K Yee; Thomas J Bleisch; Jose E Lopez; Scott A Jones; Norman E Hughes; Brian S Muehl; Charles W Lugar; Terry L Moore; Pamela K Shetler; Richard W Zink; John J Osborne; Chahrzad Montrose-Rafizadeh; Nita Patel; Andrew G Geiser; Rachelle J Sells Galvin; Jeffrey A Dodge
Journal:  ACS Med Chem Lett       Date:  2010-12-09       Impact factor: 4.345

3.  Evaluation of Bronopol and Disulfiram as Potential Candidatus Liberibacter asiaticus Inosine 5'-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic.

Authors:  Jing Nan; Shaoran Zhang; Ping Zhan; Ling Jiang
Journal:  Molecules       Date:  2020-05-14       Impact factor: 4.411

  3 in total

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