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Literature DB >> 16482618

E-cadherin in gastric cancer.

Abstract

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail.

Entities: Disease Species

Mesh：

Substances：
Cadherins

Year: 2006 PMID： 16482618 PMCID： PMC4066027 DOI： 10.3748/wjg.v12.i2.199

Source DB: PubMed Journal: World J Gastroenterol ISSN： 1007-9327 Impact factor: 5.742

47 in total

Review 1. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity.

Authors: T Yagi; M Takeichi
Journal: Genes Dev Date: 2000-05-15 Impact factor: 11.361

Review 2. Wnt signaling and cancer.

Authors: P Polakis
Journal: Genes Dev Date: 2000-08-01 Impact factor: 11.361

Review 3. E-cadherin-catenin cell-cell adhesion complex and human cancer.

Authors: B P Wijnhoven; W N Dinjens; M Pignatelli
Journal: Br J Surg Date: 2000-08 Impact factor: 6.939

4. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression.

Authors: A Cano; M A Pérez-Moreno; I Rodrigo; A Locascio; M J Blanco; M G del Barrio; F Portillo; M A Nieto
Journal: Nat Cell Biol Date: 2000-02 Impact factor: 28.824

5. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells.

Authors: E Batlle; E Sancho; C Francí; D Domínguez; M Monfar; J Baulida; A García De Herreros
Journal: Nat Cell Biol Date: 2000-02 Impact factor: 28.824

6. Interleukin-1 polymorphisms associated with increased risk of gastric cancer.

Authors: E M El-Omar; M Carrington; W H Chow; K E McColl; J H Bream; H A Young; J Herrera; J Lissowska; C C Yuan; N Rothman; G Lanyon; M Martin; J F Fraumeni; C S Rabkin
Journal: Nature Date: 2000-03-23 Impact factor: 49.962

7. Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer.

Authors: W M Grady; J Willis; P J Guilford; A K Dunbier; T T Toro; H Lynch; G Wiesner; K Ferguson; C Eng; J G Park; S J Kim; S Markowitz
Journal: Nat Genet Date: 2000-09 Impact factor: 38.330

8. H pylori infection is associated with downregulation of E-cadherin, a molecule involved in epithelial cell adhesion and proliferation control.

Authors: A M Terrés; J M Pajares; D O'Toole; S Ahern; D Kelleher
Journal: J Clin Pathol Date: 1998-05 Impact factor: 3.411

Review 9. Regulation of cadherin adhesive activity.

Authors: B M Gumbiner
Journal: J Cell Biol Date: 2000-02-07 Impact factor: 10.539

10. Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production.

Authors: A Hmadcha; F J Bedoya; F Sobrino; E Pintado
Journal: J Exp Med Date: 1999-12-06 Impact factor: 14.307

33 in total

Review 1. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer.

Authors: Yuji Toiyama; Yoshinaga Okugawa; Ajay Goel
Journal: Biochem Biophys Res Commun Date: 2014-08-13 Impact factor: 3.575

2. Snail1 correlates with patient outcomes in E-cadherin-preserved gastroesophageal junction adenocarcinoma.

Authors: H Dong; L Xie; C Tang; S Chen; Q Liu; Q Zhang; W Zheng; Z Zheng; H Zhang
Journal: Clin Transl Oncol Date: 2013-12-20 Impact factor: 3.405

3. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion.

Authors: Benjamin Hoy; Martin Löwer; Christiane Weydig; Gert Carra; Nicole Tegtmeyer; Tim Geppert; Peter Schröder; Norbert Sewald; Steffen Backert; Gisbert Schneider; Silja Wessler
Journal: EMBO Rep Date: 2010-09-03 Impact factor: 8.807

4. All-trans retinoic acid (ATRA) downregulates MMP-9 by modulating its regulatory molecules.

Authors: Anindita Dutta; Triparna Sen; Amitava Chatterjee
Journal: Cell Adh Migr Date: 2010 Jul-Sep Impact factor: 3.405

Review 5. Methylation-mediated gene silencing as biomarkers of gastric cancer: a review.

Authors: Jun Nakamura; Tomokazu Tanaka; Yoshihiko Kitajima; Hirokazu Noshiro; Kohji Miyazaki
Journal: World J Gastroenterol Date: 2014-09-14 Impact factor: 5.742

Review 6. Epigenetic Mechanisms and Events in Gastric Cancer-Emerging Novel Biomarkers.

Authors: Hasan Raza Kazmi; Soni Kumari; Satendra Tiwari; A Khanna; Gopeshwar Narayan
Journal: Pathol Oncol Res Date: 2018-03-19 Impact factor: 3.201

7. Molecular epidemiology of genetic susceptibility to gastric cancer: focus on single nucleotide polymorphisms in gastric carcinogenesis.

Authors: Ming Yin; Zhibin Hu; Dongfeng Tan; Jaffer A Ajani; Qingyi Wei
Journal: Am J Transl Res Date: 2009-01-01 Impact factor: 4.060