BACKGROUND: Differences in tumor behavior, ranging from indolent to aggressive, create a need for novel prognostic biomarkers. BAG-1 is a co-chaperone that regulates the activity of Hsp70, Bcl-2, Raf-1, growth factor, and steroid receptors (e.g., the Androgen Receptor). METHODS: Using immunohistochemical method, we explored BAG-1 expression in prostate cancers and its association with clinicopathological parameters. RESULTS: BAG-1 immunostaining was elevated in prostate cancer compared to normal prostatic epithelium. Higher nuclear BAG-1 in hormone-refractory (n = 34) compared to localized untreated tumors (n = 58) (P < 0.0001) suggested that upregulation of the nuclear isoform may contribute to disease progression. In 64 early-stage patients (T2N0M0) treated with external-beam irradiation, cytosolic BAG-1 correlated with higher pretreatment levels of serum Prostate specific antigen (P = 0.04) and shorter time to disease progression (P = 0.00004). CONCLUSIONS: Increased cytosolic and nuclear BAG-1 expression may denote more aggressive variants of prostate cancer.
BACKGROUND: Differences in tumor behavior, ranging from indolent to aggressive, create a need for novel prognostic biomarkers. BAG-1 is a co-chaperone that regulates the activity of Hsp70, Bcl-2, Raf-1, growth factor, and steroid receptors (e.g., the Androgen Receptor). METHODS: Using immunohistochemical method, we explored BAG-1 expression in prostate cancers and its association with clinicopathological parameters. RESULTS:BAG-1 immunostaining was elevated in prostate cancer compared to normal prostatic epithelium. Higher nuclear BAG-1 in hormone-refractory (n = 34) compared to localized untreated tumors (n = 58) (P < 0.0001) suggested that upregulation of the nuclear isoform may contribute to disease progression. In 64 early-stage patients (T2N0M0) treated with external-beam irradiation, cytosolic BAG-1 correlated with higher pretreatment levels of serum Prostate specific antigen (P = 0.04) and shorter time to disease progression (P = 0.00004). CONCLUSIONS: Increased cytosolic and nuclear BAG-1 expression may denote more aggressive variants of prostate cancer.
Authors: Stefania Staibano; Massimo Mascolo; Maria Di Benedetto; Maria Luisa Vecchione; Gennaro Ilardi; Giuseppe Di Lorenzo; Riccardo Autorino; Vincenzo Salerno; Antonella Morena; Alba Rocco; Maria Caterina Turco; Emilio Morelli Journal: Tumour Biol Date: 2010-06-10
Authors: Xiao-Yong Zhang; Harla K Pfeiffer; Hestia S Mellert; Timothy J Stanek; Robyn T Sussman; Alpana Kumari; Duonan Yu; Isidore Rigoutsos; Andrei Thomas-Tikhonenko; Hans E Seidel; Lewis A Chodosh; Graham Packham; Renato Baserga; Steven B McMahon Journal: Mol Cell Biol Date: 2011-10-10 Impact factor: 4.272
Authors: Anja Bruchmann; Corinna Roller; Tamara Vanessa Walther; Georg Schäfer; Sara Lehmusvaara; Tapio Visakorpi; Helmut Klocker; Andrew C B Cato; Danilo Maddalo Journal: BMC Cancer Date: 2013-03-01 Impact factor: 4.430