| Literature DB >> 16482091 |
Stephan Nickell1, Christine Kofler, Andrew P Leis, Wolfgang Baumeister.
Abstract
Cryo-electron tomography is an emerging imaging technique that has unique potential for molecular cell biology. At the present resolution of 4-5 nm, large supramolecular structures can be studied in unperturbed cellular environments and, in the future, it will become possible to map molecular landscapes inside cells in a more comprehensive manner. 'Visual proteomics' aims to complement and extend mass-spectrometry-based inventories, and to provide a quantitative description of the macromolecular interactions that underlie cellular functions.Mesh：
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Year: 2006 PMID： 16482091 DOI： 10.1038/nrm1861
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444