PURPOSE OF REVIEW: In this review, we summarize some of the recent advances in our understanding of the biology of endothelial progenitor cells, and discuss the potential relevance of these progenitor cells for endothelial function and associated microvascular abnormalities that can form the structural basis of essential hypertension. RECENT FINDINGS: Both in experimental models of hypertension and in patients with hypertension, the function of endothelial progenitor cells is impaired. Also, some antihypertensive drugs that have been associated with reversal of endothelial function and microvascular rarefaction appear to correct endothelial progenitor cell dysfunction. SUMMARY: While information on endothelial progenitor biology is still limited in patients with hypertension in comparison with, for example, patients with coronary artery disease, it is a topic that warrants the attention of researchers in the hypertension field, as it may have important implications for the development of organ damage, and potentially could be linked to the pathogenesis of hypertension itself.
PURPOSE OF REVIEW: In this review, we summarize some of the recent advances in our understanding of the biology of endothelial progenitor cells, and discuss the potential relevance of these progenitor cells for endothelial function and associated microvascular abnormalities that can form the structural basis of essential hypertension. RECENT FINDINGS: Both in experimental models of hypertension and in patients with hypertension, the function of endothelial progenitor cells is impaired. Also, some antihypertensive drugs that have been associated with reversal of endothelial function and microvascular rarefaction appear to correct endothelial progenitor cell dysfunction. SUMMARY: While information on endothelial progenitor biology is still limited in patients with hypertension in comparison with, for example, patients with coronary artery disease, it is a topic that warrants the attention of researchers in the hypertension field, as it may have important implications for the development of organ damage, and potentially could be linked to the pathogenesis of hypertension itself.
Authors: Maria W Skrzypkowska; Monika E Ryba-Stanisławowska; Bartosz Słomiński; Piotr G Gutknecht; Janusz Siebert; Jolanta M Myśliwska Journal: J Hum Hypertens Date: 2017-11-30 Impact factor: 3.012
Authors: Petra J Mateos-Cáceres; Jose J Zamorano-León; Pablo Rodríguez-Sierra; Carlos Macaya; Antonio J López-Farré Journal: Int J Hypertens Date: 2011-10-20 Impact factor: 2.420
Authors: Marina A Aleksinskaya; Ernst E H van Faassen; Jelly Nelissen; Ben J A Janssen; Jo G R De Mey; Roeland Hanemaaijer; Ton Rabelink; Anton Jan van Zonneveld Journal: PLoS One Date: 2013-03-12 Impact factor: 3.240