BACKGROUND:Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. AIM: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. METHODS: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. RESULTS: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. CONCLUSION:Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.
RCT Entities:
BACKGROUND:Permethrin, a pyrethroid insecticide, is not yet available in Iran and may be a useful substitute for the control of scabies in Iran. AIM: To compare the efficacy of topical lindane with topical permethrin in the treatment of scabies in a population in Iran. METHODS: In a double-blind, randomized study, all consecutive patients with scabies were randomized into two groups. One group and their family contacts received 1% lindane cream, and the other group and their family contacts were treated with topical 5% permethrin cream. Subsequently, patients were followed up at 2- and 4-week post-treatment. RESULTS: Of the 99 patients enrolled in the study, 47 patients received 1% lindane cream, and 52 patients were treated topically with 5% permethrin cream. Permethrin provided an improvement rate of 84.6% after two weeks, whereas lindane was effective only in 48.9% of patients. CONCLUSION:Permethrin (5%) cream was found to be significantly more effective in the treatment of scabies in comparison with lindane in this study, and it seems that it could be an alternative treatment.
Authors: Narendra P Bachewar; Vijay R Thawani; Smita N Mali; Kunda J Gharpure; Vaishali P Shingade; Ganesh N Dakhale Journal: Indian J Pharmacol Date: 2009-02 Impact factor: 1.200
Authors: Philippa J May; Steven Y C Tong; Andrew C Steer; Bart J Currie; Ross M Andrews; Jonathan R Carapetis; Asha C Bowen Journal: Trop Med Int Health Date: 2019-01-28 Impact factor: 2.622