Medication-free research in early episode schizophrenia: why on earth would I choose to participate in such research?

The author concurs with Bola's conclusion that "a categorical prohibition of medication-free research in early episode schizophrenia on the ethical grounds of harm to human subjects should probably be reconsidered" on a case-by-case basis. The point that informed choice is rarely considered in the informed consent process is made. Several recommendations are made on how to augment the informed consent process and enhance the decision making of research participants.