Literature DB >> 16481526

Short- and long-term immune responses of CD-1 outbred mice to the scrub typhus DNA vaccine candidate: p47Kp.

Guang Xu1, Suchismita Chattopadhyay, Ju Jiang, Teik-Chye Chan, Chien-Chung Chao, Wei-Mei Ching, Allen L Richards.   

Abstract

Orientia tsutsugamushi is an obligate intracellular bacterium that is the causative agent of scrub typhus. To develop an effective vaccine to prevent or ameliorate scrub typhus, knowledge of the protective immune response to O. tsutsugamushi needs to be ascertained. Our laboratory has demonstrated that the DNA vaccine vector pVR1012 carrying the O. tsutsugamushi Karp strain 47-kDa protein gene (p47Kp) consistently provides outbred mice protection against homologous challenge.

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Year:  2005        PMID： 16481526     DOI： 10.1196/annals.1355.043

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  6 in total

1.  Diversity of the 47-kD HtrA nucleic acid and translated amino acid sequences from 17 recent human isolates of Orientia.

Authors:  Ju Jiang; Daniel H Paris; Stuart D Blacksell; Nuntipa Aukkanit; Paul N Newton; Rattanaphone Phetsouvanh; Leonard Izzard; John Stenos; Stephen R Graves; Nicholas P J Day; Allen L Richards
Journal:  Vector Borne Zoonotic Dis       Date:  2013-04-16       Impact factor: 2.133

2.  Comparison of Lethal and Nonlethal Mouse Models of Orientia tsutsugamushi Infection Reveals T-Cell Population-Associated Cytokine Signatures Correlated with Lethality and Protection.

Authors:  Alison Luce-Fedrow; Suchismita Chattopadhyay; Teik-Chye Chan; Gregory Pearson; John B Patton; Allen L Richards
Journal:  Trop Med Infect Dis       Date:  2021-07-02

3.  A nonhuman primate scrub typhus model: protective immune responses induced by pKarp47 DNA vaccination in cynomolgus macaques.

Authors:  Daniel H Paris; Suchismita Chattopadhyay; Ju Jiang; Pruksa Nawtaisong; John S Lee; Esterlina Tan; Eduardo Dela Cruz; Jasmin Burgos; Rodolfo Abalos; Stuart D Blacksell; Eric Lombardini; Gareth D Turner; Nicholas P J Day; Allen L Richards
Journal:  J Immunol       Date:  2015-01-19       Impact factor: 5.422

4.  A Recombinant 47-kDa Outer Membrane Protein Induces an Immune Response against Orientia tsutsugamushi Strain Boryong.

Authors:  Sangho Choi; Hang Jin Jeong; Kyu-Jam Hwang; Byoungchul Gill; Young Ran Ju; Yeong Seon Lee; Jeongmin Lee
Journal:  Am J Trop Med Hyg       Date:  2017-07       Impact factor: 2.345

5.  Characterization of the rhesus macaque (Macaca mulatta) scrub typhus model: Susceptibility to intradermal challenge with the human pathogen Orientia tsutsugamushi Karp.

Authors:  Piyanate Sunyakumthorn; Suwit J Somponpun; Rawiwan Im-Erbsin; Tippawan Anantatat; Kemajittra Jenjaroen; Susanna J Dunachie; Eric D Lombardini; Robin L Burke; Stuart D Blacksell; James W Jones; Carl J Mason; Allen L Richards; Nicholas P J Day; Daniel H Paris
Journal:  PLoS Negl Trop Dis       Date:  2018-03-09

6.  An intradermal inoculation model of scrub typhus in Swiss CD-1 mice demonstrates more rapid dissemination of virulent strains of Orientia tsutsugamushi.

Authors:  Piyanate Sunyakumthorn; Daniel H Paris; Teik-Chye Chan; Margaret Jones; Alison Luce-Fedrow; Suchismita Chattopadhyay; Ju Jiang; Tippawan Anantatat; Gareth D H Turner; Nicholas P J Day; Allen L Richards
Journal:  PLoS One       Date:  2013-01-16       Impact factor: 3.240
  6 in total

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