Literature DB >> 16481493

Identification, cloning, and expression of potential diagnostic markers for Q fever.

C C Chao1, H W Chen, X Li, W B Xu, B Hanson, W M Ching.   

Abstract

The clinical diagnosis of Q fever is difficult. Whole cell antigens are currently used in several serological methods, but antigens are limited due to the hazardous nature of Coxiella burnetii cultivation. In this report, we described the method of detecting immunodominant antigens of C. burnetii by using proteomic techniques with patient sera, and cloning and expressing the selected antigens using a novel vector known for its ease of expression, purification, and downstream application.

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Year:  2005        PMID： 16481493     DOI： 10.1196/annals.1355.010

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  6 in total

1.  Proteomics paves the way for Q fever diagnostics.

Authors:  Malgorzata Kowalczewska; Zuzana Sekeyová; Didier Raoult
Journal:  Genome Med       Date:  2011-07-30       Impact factor: 11.117

2.  Potential serodiagnostic markers for Q fever identified in Coxiella burnetii by immunoproteomic and protein microarray approaches.

Authors:  Xiaolu Xiong; Xile Wang; Bohai Wen; Stephen Graves; John Stenos
Journal:  BMC Microbiol       Date:  2012-03-16       Impact factor: 3.605

Review 3.  Q fever in China: a systematic review, 1989-2013.

Authors:  H S El-Mahallawy; G Lu; P Kelly; D Xu; Y Li; W Fan; C Wang
Journal:  Epidemiol Infect       Date:  2014-10-02       Impact factor: 4.434

4.  Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine.

Authors:  Anja Scholzen; Guilhem Richard; Leonard Moise; Laurie A Baeten; Patrick M Reeves; William D Martin; Timothy A Brauns; Christine M Boyle; Susan Raju Paul; Richard Bucala; Richard A Bowen; Anja Garritsen; Anne S De Groot; Ann E Sluder; Mark C Poznansky
Journal:  Front Immunol       Date:  2019-02-15       Impact factor: 7.561

5.  In the Search of Potential Serodiagnostic Proteins to Discriminate Between Acute and Chronic Q Fever in Humans. Some Promising Outcomes.

Authors:  Anna Psaroulaki; Eirini Mathioudaki; Iosif Vranakis; Dimosthenis Chochlakis; Emmanouil Yachnakis; Sofia Kokkini; Hao Xie; Georgios Tsiotis
Journal:  Front Cell Infect Microbiol       Date:  2020-09-18       Impact factor: 5.293

6.  Analysis of recombinant proteins for Q fever diagnostics.

Authors:  Halie K Miller; Gilbert J Kersh
Journal:  Sci Rep       Date:  2020-12-01       Impact factor: 4.996
  6 in total

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