| Literature DB >> 16481166 |
Jagabandhu Das1, Chunjian Liu, Robert V Moquin, James Lin, Joseph A Furch, Steven H Spergel, Arthur M Doweyko, Kim W McIntyre, David J Shuster, Kathleen D O'Day, Becky Penhallow, Chen-Yi Hung, Steven B Kanner, Tai-An Lin, John H Dodd, Joel C Barrish, John Wityak.
Abstract
A series of structurally novel aminothiazole based small molecule inhibitors of Itk were prepared to elucidate their structure-activity relationships (SARs), selectivity and cell activity in inhibiting IL-2 secretion in a Jurkat T-cell assay. Compound 2 is identified as a potent and selective Itk inhibitor which inhibits anti-TCR antibody induced IL-2 production in mice in vivo.Entities:
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Year: 2006 PMID： 16481166 DOI： 10.1016/j.bmcl.2006.01.115
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823