Literature DB >> 16481164

Substrate specificity of strictosidine synthase.

Elizabeth McCoy1, M Carmen Galan, Sarah E O'Connor.   

Abstract

Strictosidine synthase catalyzes a Pictet-Spengler reaction in the first step in the biosynthesis of terpene indole alkaloids to generate strictosidine. The substrate requirements for strictosidine synthase are systematically and quantitatively examined and the enzymatically generated compounds are processed by the second enzyme in this biosynthetic pathway.

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Year:  2006        PMID： 16481164     DOI： 10.1016/j.bmcl.2006.01.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  23 in total

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4.  The evolution of function in strictosidine synthase-like proteins.

Authors:  Michael A Hicks; Alan E Barber; Lesley-Ann Giddings; Jenna Caldwell; Sarah E O'Connor; Patricia C Babbitt
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6.  Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle.

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7.  Precursor-Directed Generation of Amidine Containing Ammosamide Analogs: Ammosamides E-P.

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Review 8.  Mechanistic advances in plant natural product enzymes.

Authors:  Aimee R Usera; Sarah E O'Connor
Journal:  Curr Opin Chem Biol       Date:  2009-07-23       Impact factor: 8.822

9.  Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis.

Authors:  Nancy Yerkes; Jia Xin Wu; Elizabeth McCoy; M Carmen Galan; Shi Chen; Sarah E O'Connor
Journal:  Bioorg Med Chem Lett       Date:  2007-11-22       Impact factor: 2.823

10.  Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis.

Authors:  Hyang-Yeol Lee; Nancy Yerkes; Sarah E O'Connor
Journal:  Chem Biol       Date:  2009-12-24
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