| Literature DB >> 16481140 |
Shinko Koishi1, Kenji Yamamoto, Hideo Matsumoto, Seiji Koishi, Youichi Enseki, Akitoshi Oya, Arata Asakura, Yutaka Aoki, Mariko Atsumi, Tomiei Iga, Jyoji Inomata, Hidetoshi Inoko, Tsukasa Sasaki, Eiji Nanba, Nobumasa Kato, Tetsuo Ishii, Kosuke Yamazaki.
Abstract
Autism is now widely accepted as a biological disorder which, by and large, starts before birth. It has been shown that serotonin (5-HT) is associated with several psychological processes and hyperserotoninemia is observed in some autistic patients. The results of previous reports about family-based association studies between the serotonin transporter (5-HTT) gene promoter polymorphism and autism are controversial. In this study, an analysis using the transmission/disequilibrium test (TDT) between the 5-HTT gene promoter polymorphism and autism in 104 trios, all ethnically Japanese, showed no significant linkage disequilibrium (P=0.17). Recently, it has been reported that some haplotypes at the serotonin transporter locus may be associated with the pathogenesis of autism. Therefore, further investigations by haplotype analyses are necessary to confirm the implications of genetic variants of the serotonin transporter in the etiology of autism.Entities:
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Year: 2006 PMID： 16481140 DOI： 10.1016/j.braindev.2005.09.003
Source DB: PubMed Journal: Brain Dev ISSN： 0387-7604 Impact factor: 1.961