| Literature DB >> 16480871 |
Arun K Ghosh1, Gary Schiltz, Ramu Sridhar Perali, Sofiya Leshchenko, Stephanie Kay, D Eric Walters, Yasuhiro Koh, Kenji Maeda, Hiroaki Mitsuya.
Abstract
A series of novel oxyindole-derived HIV-1 protease inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor 2 (TMC-114) bound to HIV-1 protease. The effects of substituents, spirocyclic rings, and ring sizes have been investigated. A number of inhibitors exhibited low nanomolar inhibitory potencies against HIV protease.Entities:
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Year: 2006 PMID： 16480871 DOI： 10.1016/j.bmcl.2006.01.011
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823