| Literature DB >> 16480867 |
Eva Altmann1, Reiner Aichholz, Claudia Betschart, Thomas Buhl, Jonathan Green, René Lattmann, Martin Missbach.
Abstract
A series of dipeptidyl nitriles as inhibitors of cathepsin K have been explored starting from lead structure 1 (Cbz-Leu-NH-CH2-CN, IC50 = 39 nM). Attachment of non-natural amino acid side chains in P1 and modification of the P3 subunit led to inhibitors with higher potency and improved pharmacokinetic properties.Entities:
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Year: 2006 PMID： 16480867 DOI： 10.1016/j.bmcl.2006.01.104
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823