| Literature DB >> 16480865 |
Tao Jiang1, Kelli L Kuhen, Karen Wolff, Hong Yin, Kimberly Bieza, Jeremy Caldwell, Badry Bursulaya, Tom Yao-Hsing Wu, Yun He.
Abstract
A novel oxindole was discovered as an HIV non-nucleoside reverse transcriptase inhibitor via HTS using a cell-based assay. Systematic structural modifications were carried out to establish its SAR. These modifications led to the identification of oxindoles with low nanomolar potency for inhibiting HIV replication. These novel and potent oxindoles could serve as advanced leads for further optimizations.Entities:
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Year: 2006 PMID： 16480865 DOI： 10.1016/j.bmcl.2006.01.073
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823