BACKGROUND: Oesophageal adenocarcinoma is the sixth leading cause of cancer-related mortality worldwide. Previously, oesophageal cancer was mainly squamous cell, presenting late with dysphagia and weight loss. AIMS: To examine the distribution of oesophageal cancer histopathology at a large, urban hospital; to determine the tumour stage and symptoms at presentation; and to evaluate the impact of endoscopic surveillance in Barrett's oesophagus. METHODS: From 1999 to 2004, all patients diagnosed with oesophageal cancer were evaluated retrospectively for demographics and tumour stage at presentation using endoscopic ultrasonography and computerized tomography. RESULTS: A total of 131 patients were included. 81% of tumours were adenocarcinomas; most localized to the distal oesophagus (97%). Patients presented with dysphagia (56%), pain (30%) and/or weight loss (16%). Irrespective of histology, locally advanced lesions accounted for most cases. Thirteen patients had lesions detected in Barrett's surveillance; these were early or intermediate stage in nine patients, but late stage in four patients. CONCLUSIONS: Adenocarcinoma has become the dominant histologic subtype, comprising 81% of proven malignancies. Despite a change in histopathology, most cancers are diagnosed at an advanced stage, presenting with dysphagia, pain and/or weight loss. Endoscopic surveillance of Barrett's oesophagus allows earlier diagnosis of cancer in most, but not all, patients.
BACKGROUND:Oesophageal adenocarcinoma is the sixth leading cause of cancer-related mortality worldwide. Previously, oesophageal cancer was mainly squamous cell, presenting late with dysphagia and weight loss. AIMS: To examine the distribution of oesophageal cancer histopathology at a large, urban hospital; to determine the tumour stage and symptoms at presentation; and to evaluate the impact of endoscopic surveillance in Barrett's oesophagus. METHODS: From 1999 to 2004, all patients diagnosed with oesophageal cancer were evaluated retrospectively for demographics and tumour stage at presentation using endoscopic ultrasonography and computerized tomography. RESULTS: A total of 131 patients were included. 81% of tumours were adenocarcinomas; most localized to the distal oesophagus (97%). Patients presented with dysphagia (56%), pain (30%) and/or weight loss (16%). Irrespective of histology, locally advanced lesions accounted for most cases. Thirteen patients had lesions detected in Barrett's surveillance; these were early or intermediate stage in nine patients, but late stage in four patients. CONCLUSIONS:Adenocarcinoma has become the dominant histologic subtype, comprising 81% of proven malignancies. Despite a change in histopathology, most cancers are diagnosed at an advanced stage, presenting with dysphagia, pain and/or weight loss. Endoscopic surveillance of Barrett's oesophagus allows earlier diagnosis of cancer in most, but not all, patients.
Authors: Tara R Semenkovich; Roheena Z Panni; Jessica L Hudson; Theodore Thomas; Leisha C Elmore; Su-Hsin Chang; Bryan F Meyers; Benjamin D Kozower; Varun Puri Journal: J Thorac Cardiovasc Surg Date: 2018-01-12 Impact factor: 5.209
Authors: Matthew Egyud; Mohamedtaki Tejani; Arjun Pennathur; James Luketich; Praveen Sridhar; Emiko Yamada; Anders Ståhlberg; Stefan Filges; Paul Krzyzanowski; Jennifer Jackson; Irina Kalatskaya; Wei Jiao; Gradon Nielsen; Zhongren Zhou; Virginia Litle; Lincoln Stein; Tony Godfrey Journal: Ann Thorac Surg Date: 2019-05-03 Impact factor: 4.330
Authors: Manisha Bajpai; Anshuman Panda; Kristen Birudaraju; James Van Gurp; Amitabh Chak; Kiron M Das; Parisa Javidian; Hana Aviv Journal: Front Genet Date: 2021-06-09 Impact factor: 4.599