Literature DB >> 1647983

A novel gamma subunit of the GABAA receptor identified using the polymerase chain reaction.

D Wilson-Shaw1, M Robinson, C Gambarana, R E Siegel, J M Sikela.   

Abstract

We have utilized a polymerase chain reaction (PCR) strategy to identify a novel subunit, gamma 3, of the GABAA receptor. The gamma 3 cDNA encodes a mature protein of 450 amino acids that contains structural features typically conserved among subunits of the GABAA receptor family. The gamma 3 subunit shares approximately 66% sequence identity with the gamma 2 subunit but only 38% and 29% with alpha 1 and beta 1 subunits, respectively. Localization of the gamma 3 mRNA indicates that it is widely distributed throughout the mouse brain in a pattern similar to that observed for mRNAs encoding the gamma 2 subunits.

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Year:  1991        PMID： 1647983     DOI： 10.1016/0014-5793(91)80687-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  11 in total

1.  Postsynaptic clustering of gamma-aminobutyric acid type A receptors by the gamma3 subunit in vivo.

Authors:  K Baer; C Essrich; J A Benson; D Benke; H Bluethmann; J M Fritschy; B Lüscher
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

2.  Stable expression of mammalian type A gamma-aminobutyric acid receptors in mouse cells: demonstration of functional assembly of benzodiazepine-responsive sites.

Authors:  K L Hadingham; P C Harkness; R M McKernan; K Quirk; B Le Bourdellès; A L Horne; J A Kemp; E A Barnard; C I Ragan; P J Whiting
Journal:  Proc Natl Acad Sci U S A       Date:  1992-07-15       Impact factor: 11.205

3.  The third gamma subunit of the gamma-aminobutyric acid type A receptor family.

Authors:  A Herb; W Wisden; H Lüddens; G Puia; S Vicini; P H Seeburg
Journal:  Proc Natl Acad Sci U S A       Date:  1992-02-15       Impact factor: 11.205

4.  Differential properties of type I and type II benzodiazepine receptors in mammalian CNS neurones.

Authors:  T Yakushiji; T Shirasaki; M Munakata; A Hirata; N Akaike
Journal:  Br J Pharmacol       Date:  1993-07       Impact factor: 8.739

5.  Molecular mechanisms of the partial allosteric modulatory effects of bretazenil at gamma-aminobutyric acid type A receptor.

Authors:  G Puia; I Ducic; S Vicini; E Costa
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

6.  Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies.

Authors:  J M Fritschy; D Benke; S Mertens; W H Oertel; T Bachi; H Möhler
Journal:  Proc Natl Acad Sci U S A       Date:  1992-08-01       Impact factor: 11.205

7.  Phenotypic consequences of deletion of the gamma 3, alpha 5, or beta 3 subunit of the type A gamma-aminobutyric acid receptor in mice.

Authors:  C T Culiat; L J Stubbs; C S Montgomery; L B Russell; E M Rinchik
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

8.  The original pink-eyed dilution mutation (p) arose in Asiatic mice: implications for the H4 minor histocompatibility antigen, Myod1 regulation and the origin of inbred strains.

Authors:  M H Brilliant; A Ching; Y Nakatsu; E M Eicher
Journal:  Genetics       Date:  1994-09       Impact factor: 4.562

9.  Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.

Authors:  E Sigel; R Baur; S Kellenberger; P Malherbe
Journal:  EMBO J       Date:  1992-06       Impact factor: 11.598

10.  Sequence of a functional invertebrate GABAA receptor subunit which can form a chimeric receptor with a vertebrate alpha subunit.

Authors:  R J Harvey; E Vreugdenhil; S H Zaman; N S Bhandal; P N Usherwood; E A Barnard; M G Darlison
Journal:  EMBO J       Date:  1991-11       Impact factor: 11.598
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