Literature DB >> 16479607

Regulation of surface CD163 expression and cellular effects of receptor mediated hemoglobin-haptoglobin uptake on human monocytes and macrophages.

Peter Ugocsai1, Stefan Barlage, Ashraf Dada, Gerd Schmitz.   

Abstract

Local dysregulation of iron metabolism is suggested to contribute to atherosclerotic lesion development through hemoglobin scavenging pathways. We evaluated the effects of CD163-mediated uptake of hemoglobin-haptoglobin (HbHp) complexes on surface CD163 and intracellular heme oxygenase-1 expression and the secretion of pro- and antiinflammatory cytokines by macrophages. We found that increased availability of HbHp complexes triggers the upregulation of surface CD163, and also results in a dose-dependent secretion of IL-6 and IL-10. (c) 2006 International Society for Analytical Cytology.

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Year:  2006        PMID： 16479607     DOI： 10.1002/cyto.a.20235

Source DB:  PubMed          Journal:  Cytometry A        ISSN： 1552-4922            Impact factor:   4.355


  11 in total

1.  Anti-inflammatory effects of octadecylamine-functionalized nanodiamond on primary human macrophages.

Authors:  A E Pentecost; C E Witherel; Y Gogotsi; K L Spiller
Journal:  Biomater Sci       Date:  2017-09-26       Impact factor: 6.843

2.  CD163, a marker of perivascular macrophages, is up-regulated by microglia in simian immunodeficiency virus encephalitis after haptoglobin-hemoglobin complex stimulation and is suggestive of breakdown of the blood-brain barrier.

Authors:  Juan T Borda; Xavier Alvarez; Mahesh Mohan; Atsuhiko Hasegawa; Andrea Bernardino; Sherrie Jean; Pyone Aye; Andrew A Lackner
Journal:  Am J Pathol       Date:  2008-02-14       Impact factor: 4.307

3.  Passively released heme from hemoglobin and myoglobin is a potential source of nutrient iron for Bordetella bronchiseptica.

Authors:  Jeffrey C Mocny; John S Olson; Terry D Connell
Journal:  Infect Immun       Date:  2007-07-30       Impact factor: 3.441

4.  Inflammation in sickle cell disease.

Authors:  Nicola Conran; John D Belcher
Journal:  Clin Hemorheol Microcirc       Date:  2018       Impact factor: 2.375

Review 5.  The mononuclear phagocyte system in homeostasis and disease: a role for heme oxygenase-1.

Authors:  Travis D Hull; Anupam Agarwal; James F George
Journal:  Antioxid Redox Signal       Date:  2014-03-03       Impact factor: 8.401

6.  Moderate Increase of Indoxyl Sulfate Promotes Monocyte Transition into Profibrotic Macrophages.

Authors:  Chiara Barisione; Silvano Garibaldi; Anna Lisa Furfaro; Mariapaola Nitti; Daniela Palmieri; Mario Passalacqua; Anna Garuti; Daniela Verzola; Alessia Parodi; Pietro Ameri; Paola Altieri; Patrizia Fabbi; Pier Francesco Ferrar; Claudio Brunelli; Violeta Arsenescu; Manrico Balbi; Domenico Palombo; Giorgio Ghigliotti
Journal:  PLoS One       Date:  2016-02-29       Impact factor: 3.240

7.  CD163 macrophage and erythrocyte contents in aspirated deep vein thrombus are associated with the time after onset: a pilot study.

Authors:  Eiji Furukoji; Toshihiro Gi; Atsushi Yamashita; Sayaka Moriguchi-Goto; Mio Kojima; Chihiro Sugita; Tatefumi Sakae; Yuichiro Sato; Toshinori Hirai; Yujiro Asada
Journal:  Thromb J       Date:  2016-11-22

8.  Precision engineering for PRRSV resistance in pigs: Macrophages from genome edited pigs lacking CD163 SRCR5 domain are fully resistant to both PRRSV genotypes while maintaining biological function.

Authors:  Christine Burkard; Simon G Lillico; Elizabeth Reid; Ben Jackson; Alan J Mileham; Tahar Ait-Ali; C Bruce A Whitelaw; Alan L Archibald
Journal:  PLoS Pathog       Date:  2017-02-23       Impact factor: 6.823

9.  Pigs Lacking the Scavenger Receptor Cysteine-Rich Domain 5 of CD163 Are Resistant to Porcine Reproductive and Respiratory Syndrome Virus 1 Infection.

Authors:  Christine Burkard; Tanja Opriessnig; Alan J Mileham; Tomasz Stadejek; Tahar Ait-Ali; Simon G Lillico; C Bruce A Whitelaw; Alan L Archibald
Journal:  J Virol       Date:  2018-07-31       Impact factor: 5.103

10.  The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes.

Authors:  Reina Kawarabayashi; Koka Motoyama; Miyuki Nakamura; Yuko Yamazaki; Tomoaki Morioka; Katsuhito Mori; Shinya Fukumoto; Yasuo Imanishi; Atsushi Shioi; Tetsuo Shoji; Masanori Emoto; Masaaki Inaba
Journal:  J Diabetes Res       Date:  2017-12-28       Impact factor: 4.011
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