Literature DB >> 1647893

A phase II study of ifosfamide and a2b-interferon in advanced non-small-cell lung cancer.

M J Lind1, S Gomm, A P Simmonds, L Ashcroft, A Kamthan, H Gurney, N Thatcher.   

Abstract

A total of 45 patients with advanced non-small-cell lung cancer were treated with a combination of 1.5 g/m2 ifosfamide given on days 1-5 every 3 weeks for four courses with 3 million IU a2b-interferon (Intron A) given s.c. three times a week for 12 weeks. Nine objective responses were seen, including two complete responses (CRs) and seven partial responses (PRs). Haematological and non-haematological toxicities were generally mild and did not necessitate discontinuation of therapy.

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Year:  1991        PMID: 1647893     DOI: 10.1007/bf00689705

Source DB:  PubMed          Journal:  Cancer Chemother Pharmacol        ISSN: 0344-5704            Impact factor:   3.333


  8 in total

1.  Phase I clinical trial of isophosphamide (NSC-109724).

Authors:  M H Cohen; P J Creaven; F Tejada; H H Hansen; F Muggia; A Mittelman; O S Selawry
Journal:  Cancer Chemother Rep       Date:  1975 Jul-Aug

2.  Interferon-mediated depression of cytochrome P-450-dependent drug biotransformation.

Authors:  G Singh; K W Renton
Journal:  Mol Pharmacol       Date:  1981-11       Impact factor: 4.436

Review 3.  Chemotherapy of non-small cell lung cancer: a reappraisal and a look to the future.

Authors:  M T Bakowski; J C Crouch
Journal:  Cancer Treat Rev       Date:  1983-09       Impact factor: 12.111

4.  Interferon affects both G1 and S+G2 in cells stimulated from quiescence to growth.

Authors:  F Balkwill; J Taylor-Papadimitriou
Journal:  Nature       Date:  1978-08-24       Impact factor: 49.962

5.  European experience with ifosfamide in non-small cell lung cancer.

Authors:  P Drings
Journal:  Semin Oncol       Date:  1989-02       Impact factor: 4.929

6.  Interferon alfa-2b-cyclophosphamide combination studies: in vitro and phase I-II clinical results.

Authors:  B G Durie; L Clouse; T Braich; M Grimm; A B Robertone
Journal:  Semin Oncol       Date:  1986-09       Impact factor: 4.929

7.  Positive interactions between human interferon and cyclophosphamide or adriamycin in a human tumor model system.

Authors:  F R Balkwill; E M Moodie
Journal:  Cancer Res       Date:  1984-03       Impact factor: 12.701

8.  Combined recombinant human interferon alpha 2 and cytotoxic agents studied in a clonogenic assay.

Authors:  C E Welander; T M Morgan; H D Homesley; P P Trotta; R J Spiegel
Journal:  Int J Cancer       Date:  1985-06-15       Impact factor: 7.396

  8 in total

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